MARROW CELL INJURY FOLLOWING Ca45 UPTAKE IN BONE
| Autor: | Sam C. Barranco, Roland F. Beers, Timothy Merz |
|---|---|
| Rok vydání: | 1968 |
| Předmět: |
Calcium Isotopes
Radioisotopes Marrow cell Pathology medicine.medical_specialty Mitotic index business.industry Mitosis Bone Marrow Cells General Medicine Rats Isotopes of calcium Andrology Radiation Injuries Experimental medicine.anatomical_structure Bone Marrow Cytology Micronucleus test Animals Medicine Radiology Nuclear Medicine and imaging Calcium-45 Bone marrow business |
| Zdroj: | American Journal of Roentgenology. 103:849-855 |
| ISSN: | 1546-3141 0361-803X |
| DOI: | 10.2214/ajr.103.4.849 |
| Popis: | The effects of Ca45 on the cells of the bone marrow in the rat were studied. Animals in 5 groups received injections of 25 µc, 50 µC, 100 µc, 200 µc, and 300 µc of Ca45, respectively. They were sacrificed at 12 hours, 24 hours, 36 hours, 2 days, 4 days, 6 days, 8 days, 12 days, 19 days, 25 days, and 32 days, and the bone marrow was removed from the tibiae and assayed for damage. The incidence of micronuclei and the changes in the mitotic index were used as an indication of radiation damage to the nucleus.The following results were obtained: A generally linear increase in micronuclei was observed with increasing activity of Ca45. Doses as low as 50 µc produced a 2.92 fold increase in micronuclei. Within the first 4 days after injection of the isotope, bone marrow from animals receiving a 300 µc dose showed about 5 times as many micronuclei as controls. When the animals treated with 25 µc were observed at 12, 24, 36, and 48 hours after injection, 4.75, 5.63, 3.00, and 1.69 fold increases, respectively, were... |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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