Mechanical Adaptability of Tumor Cells in Metastasis
| Autor: | Valentin Gensbittel, Sébastien Harlepp, Ignacio Busnelli, Jacky G. Goetz, Jochen Guck, Martin Kräter |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
Cell
Tumor cells Biology Mechanotransduction Cellular General Biochemistry Genetics and Molecular Biology Metastasis 03 medical and health sciences 0302 clinical medicine Cell Movement Neoplasms Cell Adhesion medicine Animals Humans Neoplasm Metastasis Molecular Biology 030304 developmental biology 0303 health sciences Intravasation Cancer Cell Biology medicine.disease Primary tumor Extravasation Biomechanical Phenomena medicine.anatomical_structure Cancer cell Cancer research 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Developmental Cell. 56:164-179 |
| ISSN: | 1534-5807 |
| Popis: | The most dangerous aspect of cancer lies in metastatic progression. Tumor cells will successfully form life-threatening metastases when they undergo sequential steps along a journey from the primary tumor to distant organs. From a biomechanics standpoint, growth, invasion, intravasation, circulation, arrest/adhesion, and extravasation of tumor cells demand particular cell-mechanical properties in order to survive and complete the metastatic cascade. With metastatic cells usually being softer than their non-malignant counterparts, high deformability for both the cell and its nucleus is thought to offer a significant advantage for metastatic potential. However, it is still unclear whether there is a finely tuned but fixed mechanical state that accommodates all mechanical features required for survival throughout the cascade or whether tumor cells need to dynamically refine their properties and intracellular components at each new step encountered. Here, we review the various mechanical requirements successful cancer cells might need to fulfill along their journey and speculate on the possibility that they dynamically adapt their properties accordingly. The mechanical signature of a successful cancer cell might actually be its ability to adapt to the successive microenvironmental constraints along the different steps of the journey. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|