Circulation of genotype-I hepatitis B virus in the primitive tribes of Arunachal Pradesh in early sixties and molecular evolution of genotype-I
| Autor: | Vidya A. Arankalle, Atul M. Walimbe, Bangari Haldipur |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Adult
Male Microbiology (medical) Hepatitis B virus Genotype Molecular Sequence Data India Genome Viral Hepacivirus Biology Serogroup Tribe (biology) medicine.disease_cause Microbiology Serology Evolution Molecular Young Adult Molecular evolution Genetics medicine Humans Molecular clock Molecular Biology Phylogeny Ecology Evolution Behavior and Systematics Recombination Genetic Whole genome sequencing Coinfection virus diseases History 20th Century Middle Aged Hepatitis B Hepatitis C Virology digestive system diseases Infectious Diseases DNA Viral Recombination |
| Zdroj: | Infection, Genetics and Evolution. 27:366-374 |
| ISSN: | 1567-1348 |
| DOI: | 10.1016/j.meegid.2014.07.036 |
| Popis: | Retrospective serologic screening of 1077 serum samples collected from the primitive tribe from north-eastern India in 1963 revealed high prevalence of HBV (15% HBsAg carrier rate) and HCV (7% anti-HCV positivity) and co-circulation of multiple HBV genotypes-A, C, D and G. Full genome sequencing classified all the G-genotype samples as genotype-I. Comparison of genotype-I-HBV full-genome sequences representing 1963 (n=5, this study) and 2005 (reported earlier) showed identical recombination break-points of genotypes-A/G/C. Genotype-C and genotype-C-fragment of I-genotype circulating in 1963 were distinctly different. The data demonstrates that the recombination events were not recent. Molecular clock analysis predicted existence of genotype-I in this tribe during 1920s. |
| Databáze: | OpenAIRE |
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