Clinical features and outcome of T-lineage acute lymphoblastic leukemia in adults: A low initial white blood cell count, as well as a high count predict decreased survival rates
| Autor: | Noriko Usui, Hideho Wada, Takanori Ueda, Yasushi Miyazaki, Masamitsu Yanada, Hitoshi Kiyoi, Sumihisa Honda, Takeshi Morii, Yoshihiro Hatta, Itsuro Jinnai, Jin Takeuchi, Mitsuhiro Matsuda, Motohiro Tsuzuki, Shuichi Miyawaki, Masaya Okada, Tomoki Naoe, Ryuzo Ohno |
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| Rok vydání: | 2007 |
| Předmět: |
Adult
Male Cancer Research medicine.medical_specialty Adolescent T-Lymphocytes Serum albumin Gastroenterology Immunophenotyping Cohort Studies Leukocyte Count Risk Factors White blood cell Internal medicine Antineoplastic Combined Chemotherapy Protocols medicine Humans Leukemia-Lymphoma Adult T-Cell Cell Lineage Prospective Studies Risk factor Prospective cohort study Survival rate Clinical Trials as Topic biology business.industry Remission Induction Hematology Middle Aged Prognosis medicine.disease Survival Rate Leukemia medicine.anatomical_structure Oncology Immunology biology.protein Female business Follow-Up Studies Cohort study |
| Zdroj: | Leukemia Research. 31:907-914 |
| ISSN: | 0145-2126 |
| Popis: | Although biological and clinical features differ between B-lineage acute lymphoblastic leukemia (ALL) and T-lineage ALL (T-ALL), there have been few reports that focused on the prognosis for T-ALL in adults, primarily due to its rarity. Here, we studied the long-term outcomes and prognostic factors specific for adult T-ALL by combining patient data from the three prospective trials conducted by the Japan Adult Leukemia Study Group (JALSG). Among 559 patients whose immunophenotypes could be evaluated, 87 (15.6%) were identified as T-ALL. Of them, 66 patients (75.8%) achieved complete remission, and relapse occurred in 41 patients. With a median follow-up for surviving patients of 7.5 years, the probability of overall survival was 35.0% at 5 years. Risk factor analysis revealed that serum albumin levels, initial white blood cell (WBC) counts, and age had independent values for predicting survival. For WBC, not only the high-count group (50 x 10(9)l(-1) or higher), but also the low-count group (less than 3 x 10(9)l(-1)) showed a significantly lower survival rates than the intermediate-count group (p=0.0055 and 0.0037, respectively). Although our findings need confirmation, these results will be helpful in the identification of prognostically distinct subgroups within adult T-ALL. |
| Databáze: | OpenAIRE |
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