Factors associated with pulmonary hypertension and long-term survival in bronchiectasis subjects
| Autor: | Serpil Öcal, Lutfi Coplu, Ahmet Ugur Demir, Arslan Öcal, Oytun Portakal, Arzu Topeli |
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| Rok vydání: | 2016 |
| Předmět: |
Pulmonary and Respiratory Medicine
Adult Male medicine.medical_specialty High-resolution computed tomography Turkey Hypertension Pulmonary Ventricular Dysfunction Right 030204 cardiovascular system & hematology Hypoxemia 03 medical and health sciences 0302 clinical medicine Risk Factors Internal medicine medicine Humans Prospective Studies Prospective cohort study Hypoxia Survival rate COPD Clinical Trials as Topic Ejection fraction Bronchiectasis medicine.diagnostic_test Endothelin-1 business.industry Middle Aged medicine.disease Pulmonary hypertension Echocardiography Doppler Oxygen Patient Outcome Assessment Survival Rate Dyspnea 030228 respiratory system Cardiology Female medicine.symptom business Tomography X-Ray Computed |
| Zdroj: | Respiratory medicine. 119 |
| ISSN: | 1532-3064 |
| Popis: | The development of pulmonary hypertension (PH) and its effect on long-term survival in bronchiectasis subjects has not been explored. The present study aims to analyze the factors associated with PH and its effect on long-term survival in bronchiectasis subjects.We prospectively evaluated 23 bronchiectasis subjects without PH and 16 with PH, as well as 20 healthy volunteers.Bronchiectasis subjects with PH were more hypoxemic and had a greater number of involved lobes in high resolution computed tomography (HRCT) than did the bronchiectasis subjects without PH (P 0.001 and P 0.001, respectively). At three years, the survival rate was 95.7% for bronchiectasis subjects without PH and 56.3% for bronchiectasis with PH, and at 5 years, these rates were 95.7% and 62.5%, respectively (P = 0.002). Multivariate Cox regression analysis revealed that only the Medical Research Council (MRC) dyspnea score was independently related to poor survival in all bronchiectasis subjects (hazard ratio: 6.98; 95% CI: 2.41-20.23; P 0.00001).Subjects with PH are more hypoxemic and have a greater number of involvements in the lobes of the lungs. Bronchiectasis subjects with PH have worse survival than do bronchiectasis subjects without PH. MRC dyspnea score is an independent predictor of long-term survival. |
| Databáze: | OpenAIRE |
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