Exposure-response relation for occupational exposure to respirable quartz and lung cancer risk : performance of a quantitative vs a semi-quantitative job-exposure matrix
| Autor: | Dirk Dahmann, Kurt Straif, Nils Plato, Raymond Vincent, Karl-Heinz Jöckel, Hans Kromhout, Lorenzo Richiardi, Per Gustavsson, Lorenzo Simonato, Wolfgang Ahrens, Dario Consonni, Benjamin Kendzia, Jack Siemiatycki, Francesco Forastiere, Simone Benhamou, Dario Mirabelli, Hermann Pohlabeln, Roel Vermeulen, Barbara Savary, Domenico Maria Cavallo, Andrea Cattaneo, Bas Bueno-de-Mesquita, Ann Olsson, Susan Peters, Isabelle Stücker, Joelle Fevotte, Jérôme Lavoué, Lützen Portengen, Pier Alberto Bertazzi, Heinz-Erich Wichmann, Irene Brüske, Paul Brennan, Beate Pesch, Thomas Brüning, Paolo Boffetta |
|---|---|
| Rok vydání: | 2011 |
| Předmět: |
education.field_of_study
business.industry Population Job-exposure matrix Public Health Environmental and Occupational Health Cumulative Exposure medicine.disease Logistic regression Toxicology Quartile Respirable Quartz Environmental health medicine Lung cancer education business Exposure assessment |
| Popis: | Objectives In order to estimate the exposure-response relation of respirable quartz and lung cancer risk, we developed a quantitative time/job/region specific job-exposure matrix (JEM) based on statistical modelling of historical exposure data. We compared the performance of this quantitative JEM (SYN-JEM) with an already available semi-quantitative general population JEM (DOM-JEM) within a study of pooled community-based lung cancer case-control studies (SYNERGY). Methods Detailed lifetime occupational and smoking history was available for 13 259 cases and 16 232 controls from 11 case-control studies from 12 European countries and Canada. Occupational histories were linked with SYN-JEM and DOM-JEM to derive estimates of cumulative exposure. ORs for lung cancer were estimated using unconditional logistic regression adjusted for age, gender, study, cigarette pack-years, time-since-quitting smoking, and ever occupational exposure to five other known lung carcinogens. Results Exposure to respirable quartz was associated with a monotonic increase in risk of lung cancer. Cumulative exposure estimates based on the quantitative SYN-JEM ranged from 0.005 to 104 mg/m3-years. Quartiles of cumulative exposure (categorised using the exposure distribution among exposed controls) showed significant elevated risks ranging from 1.16 to 1.40. SYN-JEM did not perform better than the ordinal DOM-JEM which provided similar ORs. Conclusions We found a positive exposure-response association between occupational exposure to respirable quartz and lung cancer in a large pooled community-based case-control study. A semi-quantitative approach showed similar results as the quantitative exposure assessment approach except that with the latter risk can be expressed in terms of mg/m3 quartz years, which would facilitate quantitative risk-assessment. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|