Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation
| Autor: | Jetta Sandeep Kumar, B. Thirupataiah, Jayesh Mudgal, Gangireddy Sujeevan Reddy, Guntipally Mounika, Kazi Amirul Hossain, Marina Rajadurai, Jessy Elizabeth Mathew, Gautham G. Shenoy, Kishore V. L. Parsa, Manojit Pal |
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| Rok vydání: | 2021 |
| Předmět: |
Allyl bromide
Aqueous solution Ligand Metals and Alloys Regioselectivity General Chemistry Bond formation Medicinal chemistry Catalysis Surfaces Coatings and Films Electronic Optical and Magnetic Materials chemistry.chemical_compound chemistry Cascade reaction Methyl vinyl ketone Materials Chemistry Ceramics and Composites |
| Zdroj: | Chemical Communications. 57:10091-10094 |
| ISSN: | 1364-548X 1359-7345 |
| Popis: | A Pd-catalysed regioselective synthesis of 4,5-disubstituted 7-membered N/O-heterocycles was achieved via the 7-endo-dig cyclization followed by C–C bond formation of 2-(1-alkynyl)phenylacetamide. The ligand/additive free cascade reaction proceeded in the presence of PdCl2 in aqueous MeCN when the separate and individual use of methyl vinyl ketone and allyl bromide generally afforded an O- and N-heterocycle, respectively. The pharmacological assay was performed to identify the first example of a 1H-benzo[d]azepin-2(3H)-one based novel inhibitor of PDE4B. |
| Databáze: | OpenAIRE |
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