An overview of in vitro dissolution/release methods for novel mucosal drug delivery systems
| Autor: | Ivan Pepić, Maja Lusina Kregar, Anita Hafner, Jasmina Lovrić, Mario Jug, Željka Vanić, Biserka Cetina-Čižmek, Jelena Filipović-Grčić |
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| Rok vydání: | 2017 |
| Předmět: |
In vitro dissolution
Chemistry Pharmaceutical Clinical Biochemistry Pharmaceutical Science 02 engineering and technology Drug action Pharmacology 030226 pharmacology & pharmacy Dosage form Analytical Chemistry Single test 03 medical and health sciences 0302 clinical medicine Drug Delivery Systems Drug Discovery Animals Humans In vitro release Ocular drug delivery system Nasal drug delivery system Oromucosal drug delivery system Vaginal drug delivery system Rectal drug delivery systems Spectroscopy Mucous Membrane Chemistry 021001 nanoscience & nanotechnology Drug Liberation Pharmaceutical Preparations Solubility Rectal administration Drug delivery Drug product 0210 nano-technology Release methods |
| Zdroj: | Journal of pharmaceutical and biomedical analysis. 147 |
| ISSN: | 1873-264X |
| Popis: | In vitro dissolution/release tests are an important tool in the drug product development phase as well as in its quality control and the regulatory approval process. Mucosal drug delivery systems are aimed to provide both local and systemic drug action via mucosal surfaces of the body and exhibit significant differences in formulation design, as well as in their physicochemical and release characteristics. Therefore it is not possible to devise a single test system which would be suitable for release testing of such complex dosage forms. This article is aimed to provide a comprehensive review of both compendial and noncompendial methods used for in vitro dissolution/release testing of novel mucosal drug delivery systems aimed for ocular, nasal, oromucosal, vaginal and rectal administration. |
| Databáze: | OpenAIRE |
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