Oxymatrine improves TNBS-induced colitis in rats by inhibiting the expression of NF-kappaB p65
| Autor: | Rui Chen, Pengcheng Xiong, Lin Shen, Zhe-Xing Shou, Jian-Fang Lv, Heng Fan, Xiong Zhuang |
|---|---|
| Rok vydání: | 2008 |
| Předmět: |
Interleukin 2
Male medicine.medical_specialty Colon Biomedical Engineering Down-Regulation Inflammation Pharmacology Biochemistry Inflammatory bowel disease Biomaterials Rats Sprague-Dawley chemistry.chemical_compound Immune system Alkaloids Downregulation and upregulation Internal medicine Genetics medicine Animals Colitis Earth-Surface Processes Chemistry Transcription Factor RelA medicine.disease Interleukin-10 Rats Interleukin 10 Endocrinology Oxymatrine Trinitrobenzenesulfonic Acid Interleukin-2 medicine.symptom Sophora Quinolizines medicine.drug |
| Zdroj: | Journal of Huazhong University of Science and Technology. Medical sciences = Hua zhong ke ji da xue xue bao. Yi xue Ying De wen ban = Huazhong keji daxue xuebao. Yixue Yingdewen ban. 28(4) |
| ISSN: | 1672-0733 |
| Popis: | Inflammatory bowel disease is thought to be regulated by the balance between Th1 and Th2 cytokines secreted by T cells, and NF-kappaB p65 also plays a predominant role in the intestinal inflammation. We evaluated the potency of oxymatrine, one of active components of Sophora Root, in inhibiting the immune responses and inflammation in 2,4,6-trinitrobenzene sulfonic acid (TNBS)-induced colitis. The inflammation was markedly ameliorated in the oxymatrine-treated rats. The level of IL-2 was increased and that of IL-10 was decreased in colon tissue in the rat model, which was reversed by the treatment of oxymatrine. Moreover, the elevated expression of NF-kappaB p65 in colon tissue in the model was also improved by oxymatrine treatment. Our results suggest that oxymatrine might be beneficial for the abnormal immune responses and inflammation by regulating the unbalance of Th1 and Th2 cytokines secretion and inhibiting the expression of NF-kappaB p65 in colon tissue. |
| Databáze: | OpenAIRE |
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