The natural history of hypertension
| Autor: | James A Hagans, Albert A. Brust |
|---|---|
| Rok vydání: | 1960 |
| Předmět: |
medicine.medical_specialty
education.field_of_study business.industry medicine.drug_class Population Diastole General Medicine medicine.disease Essential hypertension eye diseases Uremia Surgery Blood pressure Pharmacotherapy Internal medicine Hypertension Cardiology medicine Humans Decompensation sense organs business Antihypertensive drug education |
| Zdroj: | The American journal of medicine. 28 |
| ISSN: | 0002-9343 |
| Popis: | 1.1. Two hundred and twelve patients with various forms of hypertension were classified according to the changes in their optic fundi and the degree of target organ involvement. They were followed up for an average period of four years, the shortest follow-up interval being two years for any one patient. During the period of observation the patients received no antihypertensive drug therapy but were given more general medical treatment as indicated. 2.2. Those with essential hypertension showed a strikingly different life expectancy, depending upon the presence or absence of sustained uremia. 3.3. In the absence of sustained uremia, the degree of change in the optic fundi and the severity of other target organ involvement seemed most markedly to influence the patient's life expectancy. 4.4. Those with elevated diastolic blood pressures, irrespective of the degree of elevation, who manifested benign changes in the optic fundi and no evidence of target organ decompensation enjoyed a life expectancy approximating that of the general population for a similar age group. 5.5. In view of these findings and the fact that there is often marked lability in the diastolic blood pressures in patients in all stages of severity of essential hypertensive disease, evaluation of drug therapy should be based upon the degree of target organ involvement and optic fundal changes rather than upon the degree of elevation of the diastolic blood pressure. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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