| Autor: |
Zhang Weihua, Lee M. Ellis, Seth Bellister, Fan Fan, Jia Lu, Ling Xia, Elizabeth Dupre, Guang Gao, Rajat Bhattacharya, Xiangcang Ye, Federico Tozzi, Lakshmi Reddy Bollu, Yunfei Zhou |
| Rok vydání: |
2023 |
| Popis: |
PDF file - 840K, Suppl. Figure 1. Conversion of CPT-11 (irinotican) to SN-38 by carboxylesterase; Suppl. Figure 2. Western blot analysis of the basal expression status of ACLy in a panel of colon cancer cell (CRC) lines; Suppl. Figure 3. Overexpression of fatty acid synthase (FASN) inhibited ACLy inhibition induced sensitization of HT29 cells to SN38; Suppl. Figure 4. Increased lipid droplets in HT29 cells that are resistant to SN38 (HT29-SNR) or oxaliplatin (HT29-OxR); Suppl. Figure 5. HT29-SNR cells exhibited enhanced de novo lipogenesis; Suppl. Figure 6. Co-targeting ACLy and AKT re-sensitized HT29-SNR cells to SN38. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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