Zopiclone Versus Nitrazepam: A Double-Blind Comparative Study of Efficacy and Tolerance in Elderly Patients with Chronic Insomnia
| Autor: | J. F. Dreyfus, Delmotte M, Klimm Hd |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Male
Nitrazepam Psychometrics Placebo Piperazines Double blind Double-Blind Method Sleep Initiation and Maintenance Disorders Physiology (medical) medicine Humans Hypnotics and Sedatives Wakefulness Aged Zopiclone Clinical Trials as Topic business.industry Drug Tolerance Comparative trial Chronic insomnia Anesthesia Drug Evaluation Female Neurology (clinical) Sleep business Azabicyclo Compounds Psychometric tests medicine.drug |
| Zdroj: | Sleep. 10:73-78 |
| ISSN: | 1550-9109 0161-8105 |
| DOI: | 10.1093/sleep/10.suppl_1.73 |
| Popis: | A randomized, double-blind, comparative trial of zopiclone versus nitrazepam was conducted in 74 geriatric chronic insomniac patients. Following a 7-day wash-out period, two parallel groups, successively received a placebo for 7 days, then either 7.5 mg zopiclone or 5 mg nitrazepam for another 7-day period. Efficacy on sleep was assessed by a sleep analogue scale and the Spiegel Sleep Questionnaire, residual effects by psychometric tests and tolerance by a standardized question, as well as by clinical and laboratory tests. Zopiclone and nitrazepam were more active than placebo on all tests of efficacy. In contrast with nitrazepam, zopiclone was devoid of effect on neurological function. In addition, the condition on awakening was better with zopiclone. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|