A universal vaccine for serogroup B meningococcus
| Autor: | Davide Serruto, Brunella Brunelli, Rino Rappuoli, Laura Santini, Elena Cartocci, Dan M. Granoff, Federica Di Marcello, Mario Contorni, Alessia Biolchi, Beatrice Aricò, Jeannette Adu-Bobie, Jo Anne Welsch, Donatella Mannucci, Daniele Veggi, Francesca Titta, Alessandro Bartalesi, Vanda Cinotti, Mariagrazia Pizza, Stefania Bambini, Barbara Capecchi, Maurizio Morandi, Vega Masignani, Elisa Ovidi, Laura Ciucchi, Francesca Ferlicca, Barbara Galli, Marzia Monica Giuliani, Enrico Luzzi, Silvana Savino, Maurizio Comanducci |
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| Rok vydání: | 2006 |
| Předmět: |
medicine.medical_treatment
MF59 Meningococcal Vaccines Meningitis Meningococcal Neisseria meningitidis Serogroup B Biology medicine.disease_cause Antibodies Sepsis Mice Microscopy Electron Transmission Antigen medicine Animals Humans Antigens Bacterial Multidisciplinary Transmission (medicine) Neisseria meningitidis Reverse vaccinology Biological Sciences medicine.disease Virology Rats Disease Models Animal Immunology Adjuvant Meningitis |
| Zdroj: | Proceedings of the National Academy of Sciences. 103:10834-10839 |
| ISSN: | 1091-6490 0027-8424 |
| DOI: | 10.1073/pnas.0603940103 |
| Popis: | Meningitis and sepsis caused by serogroup B meningococcus are two severe diseases that still cause significant mortality. To date there is no universal vaccine that prevents these diseases. In this work, five antigens discovered by reverse vaccinology were expressed in a form suitable for large-scale manufacturing and formulated with adjuvants suitable for human use. The vaccine adjuvanted by aluminum hydroxide induced bactericidal antibodies in mice against 78% of a panel of 85 meningococcal strains representative of the global population diversity. The strain coverage could be increased to 90% and above by the addition of CpG oligonucleotides or by using MF59 as adjuvant. The vaccine has the potential to conquer one of the most devastating diseases of childhood. |
| Databáze: | OpenAIRE |
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