Development of the Metabolic Syndrome: Study Design and Baseline Data of the Lufthansa Prevention Study (LUPS), A Prospective Observational Cohort Survey
Autor: | Jörg Heeren, Nikolaus Marx, Anett Frisch, Volker Harth, Jan Gebhard, Claudia Terschüren, Jorg Kotzka, Dirk Müller-Wieland, Alexandra M. Preisser, Ludger Scheja, Barbara Sawitzky-Rose, Heiko Becher, J Haas, Birgit Knebel, Monika Töller, Bernd Löwe, Maximilian von Karais, Johannes Hengelbrock, Eik Vettorazzi, Matthias Rose, Christiane Altenburg, Hans O. Pinnschmidt, Janine Burchard, Karl Wegscheider |
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Rok vydání: | 2018 |
Předmět: |
Adult
Blood Glucose Male 0301 basic medicine medicine.medical_specialty Endocrinology Diabetes and Metabolism 030209 endocrinology & metabolism 03 medical and health sciences 0302 clinical medicine Endocrinology Risk Factors Germany Internal medicine Internal Medicine medicine Humans Medical history Prospective Studies Life Style Depression (differential diagnoses) Dyslipidemias Metabolic Syndrome Depression business.industry General Medicine Middle Aged Anthropometry medicine.disease Health Surveys Clinical trial Cross-Sectional Studies Early Diagnosis 030104 developmental biology Research Design Obesity Abdominal Cohort Female Observational study Insulin Resistance Metabolic syndrome business Psychosocial |
Zdroj: | Experimental and Clinical Endocrinology & Diabetes. 128:777-787 |
ISSN: | 1439-3646 0947-7349 |
Popis: | The Lufthansa Prevention Study (LUPS) study is a prospective observation of a healthy worker cohort to identify early changes in metabolism leading to the Metabolic Syndrome (MetS) and to analyze their relation to behavioral factors like nutrition, physical activity, psychological status, and to underlying genetic conditions. The LUPS study recruited a sample of 1.962 non-diabetic healthy adults between 25–60 years, employed at a flight base of Lufthansa Technik GmbH in Hamburg, Germany. Baseline assessments included anthropometric measures, blood and urine samples and medical history. Psychosocial variables, dietary habits and life-style risk factors were assessed via self-reported questionnaires.In this report we describe the study design and present baseline parameters including the prevalence of the MetS using different classification criteria. The MetS was present in 20% of male and 12% of female subjects according to the ‘Harmonizing the metabolic syndrome’ definition. The prevalence varies between 2.6% in male and 2.3% in female subjects up to 48% in male and 41% in female subjects according to different classification criteria of MetS.In conclusion, this first cross-sectional view on the LUPS data confirms the expectation that this cohort is rather healthy and thus provides the opportunity to analyze early changes associated with the development of the MetS. The LUPS study is registered as a clinical trial NCT01313156. |
Databáze: | OpenAIRE |
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