ELN 2017 classification significantly impacts the risk of early death in acute myeloid leukemia patients receiving intensive induction chemotherapy

Autor:	Naama Keren-Froim, Gabriel Heering, Gal Sharvit, Maya Zlotnik, Arnon Nagler, Avichai Shimoni, Abraham Avigdor, Jonathan Canaani
Rok vydání:	2022
Předmět:	Adult Aged 80 and over Male Risk Induction Chemotherapy Hematology General Medicine Middle Aged Prognosis Vascular Endothelial Growth Factor Receptor-3 Leukemia Myeloid Acute Young Adult Risk Factors Mutation CCAAT-Enhancer-Binding Proteins Humans Female Aged
Zdroj:	Annals of Hematology. 101:309-316
ISSN:	1432-0584 0939-5555
Popis:	Early mortality remains a challenging therapeutic facet of the initial induction phase of intensive chemotherapy in patients with acute myeloid leukemia (AML). The impact of standard molecular evaluation and risk category of the European LeukemiaNet (ELN) 2017 classification model on early mortality has not been rigorously evaluated thus far. We reviewed the medical records of 320 consecutive adult patients with newly diagnosed AML treated with intensive induction chemotherapy in our center from 2007 to 2021. The median age was 56 years; 33 patients (10%) died during induction. Patient age, white blood cell count, hemoglobin level, platelet level, creatinine, uric acid, lactate dehydrogenase serum levels, and FLT3-ITD and CEBPA mutational status did not significantly impact early mortality. NPM1
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c4146924c1d777147e5c6f06adaedc8 https://doi.org/10.1007/s00277-021-04716-4 Zobrazit plný text záznamu Full text from SpringerLink