Syphilis in the Setting of Anti-tumor Necrosis Factor Alpha Therapy
| Autor: | Monica Quintana-Codina, Ana Iglesias-Plaza, Montse Salleras-Redonnet, Javier García-Miguel, Maribel Iglesias-Sancho |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male medicine.medical_specialty Neurosyphilis 03 medical and health sciences 0302 clinical medicine medicine Humans Spondylitis Ankylosing Syphilis Adverse effect 030203 arthritis & rheumatology Ankylosing spondylitis medicine.diagnostic_test business.industry Lumbar puncture Tumor Necrosis Factor-alpha Antibodies Monoclonal General Medicine medicine.disease Dermatology Trunk Golimumab 030211 gastroenterology & hepatology Tumor necrosis factor alpha business medicine.drug |
| Zdroj: | Reumatologia clinica. 15(6) |
| ISSN: | 2173-5743 |
| Popis: | Inhibitors of tumor necrosis factor-alpha (anti-TNF-alpha) are widely used in different medical specialties. The main adverse effect of these agents is the increased risk of infection. We report the case of a 30-year-old man with ankylosing spondylitis who had begun receiving golimumab two weeks earlier. He presented with a 10-day history of salmon-colored lesions on trunk, palms and soles. The clinical suspicion was secondary syphilis. Treponemal and nontreponemal tests confirmed the diagnosis of syphilis. Lumbar puncture was also performed, although there was no neurological involvement, to rule out neurosyphilis. Cases of syphilis in patients in treatment with TNF-alpha inhibitors are uncommon in the literature and there are no established protocols. |
| Databáze: | OpenAIRE |
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