Plant-derived substances in the fight against infections caused by Candida species
| Autor: | Maria Rapala-Kozik, Kinga Ceballos, Ibeth Guevara-Lora, Miriam González-González, Wiktoria Sidlo, Grazyna Bras, Justyna Karkowska-Kuleta |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Antifungal Agents Hypha plant extracts Phytochemicals 030106 microbiology Candida spp Defence mechanisms Secondary Metabolism Virulence Review Biology Bacterial Adhesion Catalysis Microbiology Inorganic Chemistry Cell wall lcsh:Chemistry 03 medical and health sciences Immune system Drug Resistance Fungal Humans Physical and Theoretical Chemistry Molecular Biology lcsh:QH301-705.5 Spectroscopy Candida Host (biology) Organic Chemistry Candidiasis Biofilm General Medicine Plants Commensalism Computer Science Applications antifungal treatment 030104 developmental biology lcsh:Biology (General) lcsh:QD1-999 Biofilms plant metabolites |
| Zdroj: | International Journal of Molecular Sciences, Vol 21, Iss 6131, p 6131 (2020) International Journal of Molecular Sciences |
| Popis: | Yeast-like fungi from the Candida genus are predominantly harmless commensals that colonize human skin and mucosal surfaces, but under conditions of impaired host immune system change into dangerous pathogens. The pathogenicity of these fungi is typically accompanied by increased adhesion and formation of complex biofilms, making candidal infections challenging to treat. Although a variety of antifungal drugs have been developed that preferably attack the fungal cell wall and plasma membrane, these pathogens have acquired novel defense mechanisms that make them resistant to standard treatment. This causes an increase in the incidence of candidiasis and enforces the urgent need for an intensified search for new specifics that could be helpful, alone or synergistically with traditional drugs, for controlling Candida pathogenicity. Currently, numerous reports have indicated the effectiveness of plant metabolites as potent antifungal agents. These substances have been shown to inhibit growth and to alter the virulence of different Candida species in both the planktonic and hyphal form and during the biofilm formation. This review focuses on the most recent findings that provide evidence of decreasing candidal pathogenicity by different substances of plant origin, with a special emphasis on the mechanisms of their action. This is a particularly important issue in the light of the currently increasing frequency of emerging Candida strains and species resistant to standard antifungal treatment. |
| Databáze: | OpenAIRE |
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