Imaging correlates of serum enzyme-linked immunoelectrotransfer blot (EITB) positivity in patients with parenchymal neurocysticercosis: results from 521 patients
| Autor: | Prabhakaran Vasudevan, Grace Rebekah, Douglas A. Drevets, Josephin Manoj, Ellen Jackson, Subashini Thamizhmaran, Anupriya Thanigachalam, Betcy Evangeline Pamela, Vedantam Rajshekhar, Hélène Carabin, Ranjith K Moorthy |
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| Rok vydání: | 2021 |
| Předmět: |
Pathology
medicine.medical_specialty 030231 tropical medicine Neurocysticercosis Antibodies Helminth Lesion 03 medical and health sciences 0302 clinical medicine Edema Parenchyma medicine Animals Humans Univariate analysis Granuloma biology business.industry Public Health Environmental and Occupational Health Cysticercus General Medicine medicine.disease Blot Infectious Diseases Multivariate Analysis biology.protein Original Article Parasitology Antibody medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | Trans R Soc Trop Med Hyg |
| ISSN: | 1878-3503 0035-9203 |
| DOI: | 10.1093/trstmh/trab091 |
| Popis: | Background The presence of perilesional edema among patients with parenchymal neurocysticercosis (pNCC) of various lesion subtypes has not been correlated with results of serum enzyme-linked immunotransfer blot (EITB) for cysticercal antibodies. Methods In total, 521 patients with pNCC were classified into solitary cysticercus granuloma (SCG), multiple lesions, at least one of which was an enhancing granuloma (GMNCC), solitary calcified cysticercal lesion (SCC) and multiple calcified cysticercal lesions (CMNCC). The proportion of EITB positivity among each lesion subtype and its association with perilesional edema were determined. Results There were significantly higher positive EITB results in patients with GMNCC (90/111, 81.1%) compared with other lesion types. Perilesional edema was associated with positive EITB in patients with CMNCC. On univariate analysis, perilesional edema and GMNCC were associated with EITB positivity. On multivariate analysis, only GMNCC (OR 7.5; 95% CI 3.5 to 16.2) was significantly associated with EITB positivity. Conclusions In patients with pNCC, the presence of perilesional edema is associated with a higher probability of a positive EITB result in patients with CMNCC, suggesting a synchronicity in the mechanisms associated with formation of perilesional edema and the antibody response in this subtype. In patients with enhancing granulomas, edema is not an independent predictor of a positive EITB, suggesting that the enhancement itself is associated with a strong antibody response. |
| Databáze: | OpenAIRE |
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