Flunarizine vs. Pizotifen in Migraine Prophylaxis: A Review of Comparative Studies
| Autor: | Harley B. Messinger, Egilius L.H. Spierings |
|---|---|
| Rok vydání: | 1988 |
| Předmět: |
medicine.medical_specialty
Migraine Disorders Pooling MEDLINE Thiophenes Pizotifen Standard deviation Migraine prophylaxis 03 medical and health sciences 0302 clinical medicine Double-Blind Method Statistical significance Internal medicine Humans Medicine 030212 general & internal medicine Flunarizine Protocol (science) Pizotyline business.industry General Medicine Neurology (clinical) business 030217 neurology & neurosurgery medicine.drug |
| Zdroj: | Cephalalgia. 8:27-30 |
| ISSN: | 1468-2982 0333-1024 |
| DOI: | 10.1177/03331024880080s806 |
| Popis: | Six double-blind studies have been published in which the efficacy of flunarizine and pizotifen were compared. In none of the studies were differences of statistical significance revealed for attack frequency. Secondary analysis of the three studies in which the same protocol was employed, using parametric tests on transformed data gave similar results. Pooling of the data in an attempt to enhance the power by enlarging the number of patients, actually decreased the power due to an increase in standard deviation. |
| Databáze: | OpenAIRE |
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