| Autor: |
Maurice Zauderer, Ernest S. Smith, Mark Paris, William J. Bowers, Terrence L. Fisher, Katya Klimatcheva, Maria Scrivens, Susan Giralico, Alan Howell, Renee Kirk, Crystal Mallow, Laurie A. Winter, Jennifer Seils, Michael A. Doherty, Christine Reilly, Janaki Veeraraghavan, Sebold Torno, Holm Bussler, Alan S. Jonason, Elizabeth E. Evans |
| Rok vydání: |
2023 |
| Popis: |
Supplementary Figure S1: SEMA4D and PLXNB1 are highly expressed in human cancer. Supplementary Figure S2: SEMA4D gradient at tumor leading edge. Supplementary Figure S3: Tumor volumes of mice selected for immune cell characterization and functional assays. Supplementary Figure S4: CD8+ T cells are required for anti-SEMA4D induced specific immune memory response to Colon26. Supplementary Figure S5: Anti-SEMA4D treatment increases the Teff:Treg ratio. Supplementary Figure S6: Minimal effective dose of MAb67 is ~ 3 mg/kg corresponds with cSEMA4D T cell saturation as a PD marker Supplementary Figure S7: Single agent anti-SEMA4D is highly effective, while immune checkpoint inhibitor antibodies are ineffective in mammary carcinoma model. Supplementary Figure S8: Proposed mechanisms of action for SEMA4D blockade. |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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