Histopathological changes in dilated ascending aorta associated with aortic valve cuspidity
| Autor: | Jan Vojáček, Lenka Zaloudkova, Pavel Zacek, Jan Gofus, Martin Dergel, Salifu Timbilla, Mikita Karalko, Marek Pojar, Václav Stejskal |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Pulmonary and Respiratory Medicine
Aortic valve medicine.medical_specialty Heart Valve Diseases 030204 cardiovascular system & hematology Pathogenesis 03 medical and health sciences 0302 clinical medicine Bicuspid aortic valve medicine.artery Internal medicine Ascending aorta medicine Humans Elective surgery Aorta Retrospective Studies Aortic dissection business.industry General Medicine medicine.disease Aortic wall medicine.anatomical_structure 030228 respiratory system Aortic Valve cardiovascular system Cardiology Surgery Aortic diameter Cardiology and Cardiovascular Medicine business Dilatation Pathologic |
| Zdroj: | European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery. 59(5) |
| ISSN: | 1873-734X |
| Popis: | OBJECTIVES Patients with a bicuspid aortic valve (BAV) often present with a dilated ascending aorta. However, the underlying pathogenesis for the observed changes in the aortic wall and the resulting aneurysmal dilation remains a subject of debate. This study aims to compare the histological abnormalities of the ascending aorta in BAV and tricuspid aortic valve (TAV) patients and their correlation with aortic diameter and patient age. METHODS A total of 376 patients from our institution’s clinical database were included in the retrospective analysis. These patients underwent either elective surgery for ascending aorta dilation or emergency surgery for aortic dissection, either isolated or with a structurally diseased aortic valve. After excision, the ascending aorta samples were analysed by a pathologist. RESULTS On histological examination, a higher degree of elastic fibre fragmentation and loss and mucoid extracellular matrix accumulation was present in the samples from TAV patients when compared with that from BAV patients (P CONCLUSIONS Our study demonstrates a greater incidence of severe histological abnormalities in TAV patients when compared with BAV patients. |
| Databáze: | OpenAIRE |
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