Long-lasting recognition memory impairment and alterations in brain levels of cytokines and BDNF induced by maternal deprivation: effects of valproic acid and topiramate
| Autor: | Maria Noêmia Martins de Lima, André Vinícius Contri Paz, Stefano Boemler Busato, Lucio Falavigna, Rose Mary Carvalho Pinheiro, Flávio Kapczinski, Rafael Dal Ponte Ferreira, Bianca Wollenhaupt de Aguiar, Nadja Schröder, Bernardo Chaves D'avila Portal |
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| Rok vydání: | 2014 |
| Předmět: |
Topiramate
Male medicine.medical_specialty Hippocampus Prefrontal Cortex Fructose Hippocampal formation Neurotrophic factors Internal medicine medicine Animals Rats Wistar Prefrontal cortex Biological Psychiatry Recognition memory Valproic Acid Maternal deprivation Memory Disorders Psychotropic Drugs Brain-Derived Neurotrophic Factor Maternal Deprivation Recognition Psychology Psychiatry and Mental health Endocrinology Neurology Exploratory Behavior Cytokines Neurology (clinical) Psychology Neuroscience Stress Psychological medicine.drug |
| Zdroj: | Journal of neural transmission (Vienna, Austria : 1996). 122(5) |
| ISSN: | 1435-1463 |
| Popis: | Exposure to stressful events early in life may have permanent deleterious consequences on nervous system function and increase the susceptibility to psychiatric conditions later in life. Maternal deprivation, commonly used as a source of neonatal stress, impairs memory in adult rats and reduces hippocampal brain-derived neurotrophic factor (BDNF) levels. Inflammatory cytokines, such as interleukins (IL) and tumor necrosis factor-α (TNF-α) have been shown to be increased in the peripheral blood of patients with psychiatric disorders. The aim of the present study was to investigate the effects of maternal separation on the levels of IL-10 and TNF-α, and BDNF in the hippocampus and prefrontal cortex of adult rats. We also evaluated the potential ameliorating properties of topiramate and valproic acid on memory deficits and cytokine and BDNF changes associated with maternal deprivation. The results indicated that, in addition to inducing memory deficits, maternal deprivation increased the levels of IL-10 in the hippocampus, and TNF-α in the hippocampus and in the cortex, and decreased hippocampal levels of BDNF, in adult life. Neither valproic acid nor topiramate were able to ameliorate memory deficits or the reduction in BDNF induced by maternal separation. The highest dose of topiramate was able to reduce IL-10 in the hippocampus and TNF-α in the prefrontal cortex, while valproate only reduced IL-10 levels in the hippocampus. These findings may have implications for a better understanding of the mechanisms associated with alterations observed in adult life induced by early stressful events, and for the proposal of novel therapeutic strategies. |
| Databáze: | OpenAIRE |
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