From CD16a Biology to Antibody-Dependent Cell-Mediated Cytotoxicity Improvement
| Autor: | Coënon, Loïs, Villalba, Martin |
|---|---|
| Přispěvatelé: | Cellules Souches, Plasticité Cellulaire, Médecine Régénératrice et Immunothérapies (IRMB), Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Université de Montpellier (UM), Institut Sainte Catherine [Avignon], Centre Hospitalier Régional Universitaire [Montpellier] (CHRU Montpellier), KARLI, Mélanie |
| Rok vydání: | 2022 |
| Předmět: |
MESH: Killer Cells
Natural MESH: Humans MESH: Immunotherapy [SDV]Life Sciences [q-bio] Receptors IgG Immunology Antibody-Dependent Cell Cytotoxicity Antibodies Monoclonal NK cells MESH: Receptors IgG MESH: Antineoplastic Agents Immunological CD16a MESH: Antibodies Monoclonal [SDV] Life Sciences [q-bio] Killer Cells Natural Antineoplastic Agents Immunological MESH: Biology MESH: Antibody-Dependent Cell Cytotoxicity Humans Immunology and Allergy monoclonal antibodies Immunotherapy cell therapy ADCC Biology |
| Zdroj: | Frontiers in Immunology Frontiers in Immunology, Frontiers, 2022, 13, pp.913215. ⟨10.3389/fimmu.2022.913215⟩ |
| ISSN: | 1664-3224 |
| DOI: | 10.3389/fimmu.2022.913215 |
| Popis: | International audience; Antibody-dependent cell-mediated cytotoxicity (ADCC) is a potent cytotoxic mechanism that is mainly mediated in humans by natural killer (NK) cells. ADCC mediates the clinical benefit of several widely used cytolytic monoclonal antibodies (mAbs), and increasing its efficacy would improve cancer immunotherapy. CD16a is a receptor for the Fc portion of IgGs and is responsible to trigger NK cell-mediated ADCC. The knowledge of the mechanism of action of CD16a gave rise to several strategies to improve ADCC, by working on either the mAbs or the NK cell. In this review, we give an overview of CD16a biology and describe the latest strategies employed to improve antibody-dependent NK cell cytotoxicity. |
| Databáze: | OpenAIRE |
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