Increasing contribution of integrated forms to total HIV DNA in blood during HIV disease progression from primary infection
| Autor: | Christine Rouzioux, Asma Essat, Véronique Avettand-Fenoel, Adeline Melard, Olivier Delelis, Tiphaine Lenfant, Marc Bary, Marine Gousset, Jean-Paul Viard, Laurence Meyer, Faroudy Boufassa, Cécile Goujard, Pauline Trémeaux |
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| Přispěvatelé: | CCSD, Accord Elsevier, Institut Cochin (IC UM3 (UMR 8104 / U1016)), Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM)-Centre National de la Recherche Scientifique (CNRS), Service de Virologie [CHU Cochin], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Cochin [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Université Paris Descartes - Faculté de Médecine (UPD5 Médecine), Université Paris Descartes - Paris 5 (UPD5), Université Sorbonne Paris Cité (USPC), Centre de recherche en épidémiologie et santé des populations (CESP), Université de Versailles Saint-Quentin-en-Yvelines (UVSQ)-Université Paris-Sud - Paris 11 (UP11)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Hôpital Paul Brousse-Institut National de la Santé et de la Recherche Médicale (INSERM), AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre), Laboratoire de Biologie et de Pharmacologie Appliquée (LBPA), École normale supérieure - Cachan (ENS Cachan)-Centre National de la Recherche Scientifique (CNRS), Centre de Diagnostic et de Thérapeutique, Hôpital de l’Hôtel-Dieu [Paris], Laboratoire de Microbiologie Clinique [AP-HP Hôpital Necker-Enfants Malades], CHU Necker - Enfants Malades [AP-HP], Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), The ANRS-PRIMO and SEROCO cohorts are sponsored by the ANRS (French National Agency for Research on AIDS and Viral Hepatitis). This work was funded by the ANRS., ANRS-SEROCO and PRIMO cohorts, Centre National de la Recherche Scientifique (CNRS)-Université Paris Descartes - Paris 5 (UPD5)-Institut National de la Santé et de la Recherche Médicale (INSERM) |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Adult
Male 0301 basic medicine Research paper Human immunodeficiency virus (HIV) Natural history HIV Infections Context (language use) medicine.disease_cause General Biochemistry Genetics and Molecular Biology 03 medical and health sciences Integrated HIV DNA 0302 clinical medicine Acquired immunodeficiency syndrome (AIDS) medicine Humans Primary HIV infection Seroconversion Proportional Hazards Models [SDV.MP.VIR] Life Sciences [q-bio]/Microbiology and Parasitology/Virology business.industry General Medicine Middle Aged medicine.disease Virology 3. Good health Acquired immunodeficiency syndrome Kinetics 030104 developmental biology Anti-Retroviral Agents Reservoirs 030220 oncology & carcinogenesis Cohort [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology HIV-1 Leukocytes Mononuclear RNA Viral Female business Viral hepatitis Total HIV DNA Hiv disease |
| Zdroj: | EBioMedicine EBioMedicine, 2019, 41, pp.455-464. ⟨10.1016/j.ebiom.2019.02.016⟩ EBioMedicine, Elsevier, 2019, 41, pp.455-464. ⟨10.1016/j.ebiom.2019.02.016⟩ |
| ISSN: | 2352-3964 |
| Popis: | International audience; BACKGROUND:In the current context of research on HIV reservoirs, offering new insights into the persistence of HIV DNA in infected cells, which prevents viral eradication, may aid in identifying cure strategies. This study aimed to describe the establishment of stable integrated forms among total HIV DNA during primary infection (PHI) and their dynamics during the natural history of infection.METHODS:Total and integrated HIV DNA were quantified in blood from 74 PHI patients and 97 recent seroconverters ( |
| Databáze: | OpenAIRE |
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