Occupational exposure to metals and risk of meningioma: a multinational case-control study

Autor: Martie van Tongeren, Geza Benke, Joachim Schüz, Martine Hours, Klaus Schlaefer, Daniel Krewski, Laurel Kincl, Maria Blettner, Lesley Richardson, Angela Chetrit, Jack Siemiatycki, Michelle C. Turner, Elisabeth Cardis, Siegal Sadetzki, Dave McLean, Brigitte Schlehofer, Sarah Fleming Fleming, Marie-Élise Parent, Jordi Figuerola
Přispěvatelé: Cancer & Radiation Epidemiology Unit, Gertner Institute, Chaim Sheba Medical Center, Sackler Faculty of Medicine, Tel Aviv University [Tel Aviv], McLaughlin Centre for Population Health Risk Assessment, University of Ottawa [Ottawa], Centre for Research in Environmental Epidemiology (CREAL), Escola Superior de Ciències Socials i de l'Empresa-Tecnocampus, Universitat Pompeu Fabra (UPF), Universitat Pompeu Fabra [Barcelona] (UPF), CIBER de Epidemiología y Salud Pública (CIBERESP), Institute of Occupational Medicine [Edinburgh] (IOM), Monash University [Clayton], University of Leeds, Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement (UMRESTTE UMR T9405), Université Claude Bernard Lyon 1 (UCBL), Université de Lyon-Université de Lyon-Institut Français des Sciences et Technologies des Transports, de l'Aménagement et des Réseaux (IFSTTAR), Oregon State University (OSU), Massey University, Institut Armand Frappier (INRS-IAF), Réseau International des Instituts Pasteur (RIIP)-Institut National de la Recherche Scientifique [Québec] (INRS), Centre Hospitalier de l'Université de Montréal (CHUM), Université de Montréal (UdeM), Unit of Environmental Epidemiology, German Cancer Research Center - Deutsches Krebsforschungszentrum [Heidelberg] (DKFZ), Institute of Medical Biostatistics, Epidemiology and Informatics, University Medical Centre Mainz, Centre International de Recherche contre le Cancer - International Agency for Research on Cancer (CIRC - IARC), Organisation Mondiale de la Santé / World Health Organization Office (OMS / WHO)
Rok vydání: 2016
Předmět:
Zdroj: Journal of Neuro-Oncology
Journal of Neuro-Oncology, Springer Verlag, 2016, 130 (3), pp.505-515. ⟨10.1007/s11060-016-2244-4⟩
ISSN: 1573-7373
0167-594X
Popis: International audience; The aim of the study was to examine associations between occupational exposure to metals and meningioma risk in the international INTEROCC study. INTEROCC is a seven-country population-based case-control study including 1906 adult meningioma cases and 5565 population controls. Incident cases were recruited between 2000 and 2004. A detailed occupational history was completed and job titles were coded into standard international occupational classifications. Estimates of mean workday exposure to individual metals and to welding fumes were assigned based on a job-exposure-matrix. Adjusted odds ratios (ORs) and 95 % confidence intervals (CIs) were estimated using conditional logistic regression. Although more controls than cases were ever exposed to metals (14 vs. 11 %, respectively), cases had higher median cumulative exposure levels. The ORs for ever vs. never exposure to any metal and to individual metals were mostly greater than 1.0, with the strongest association for exposure to iron (OR 1.26, 95 % CI 1.0-1.58). In women, an increased OR of 1.70 (95 % CI 1.0-2.89) was seen for ever vs never exposure to iron (OR in men 1.19, 95 % CI 0.91-1.54), with positive trends in relation with both cumulative and duration of exposure. These results remained after consideration of other occupational metal or chemical co-exposures. In conclusion, an apparent positive association between occupational exposure to iron and meningioma risk was observed, particularly among women. Considering the fact that meningioma is a hormone dependent tumor, the hypothesis that an interaction between iron and estrogen metabolism may be a potential mechanism for a carcinogenic effect of iron should be further investigated.
Databáze: OpenAIRE
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