Elevation of IL-12 p40 and its antibody in myasthenia gravis with thymoma
| Autor: | Hiroaki Yoshikawa, Masaharu Takamori, Katsuaki Sato, Takahiro Maruta, Yasuhiro Suzuki, Masahito Yamada, Hideto Watanabe, Shigeki Edahiro, Kazuo Iwasa, Yutaka Furukawa, Shizuka Takaoka |
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| Rok vydání: | 2005 |
| Předmět: |
Adult
Male Thymoma Adolescent medicine.medical_treatment Immunology Th2 Cells Immunopathology Myasthenia Gravis medicine Immunology and Allergy Humans Child Aged Autoantibodies Aged 80 and over biology business.industry Autoantibody Interleukin hemic and immune systems Middle Aged Th1 Cells medicine.disease Interleukin-12 Myasthenia gravis Up-Regulation Thymectomy Protein Subunits Neurology Interleukin 12 biology.protein Female Neurology (clinical) Antibody business |
| Zdroj: | Journal of neuroimmunology. 175(1-2) |
| ISSN: | 0165-5728 |
| Popis: | We examined the serum levels of cytokines, interferon (IFN)-alpha, IFN-gamma, interleukin (IL)-4, IL-12 p40, and IL-12 p70; those that affect the T helper 1 and 2 balance in patients with myasthenia gravis (MG). Among the cytokines tested, only IL-12 p40, together with the serum titer of anti-IL-12 p40 antibody, was significantly elevated in MG with thymoma. Their elevation was independent of the histopathology of thymoma. Thymectomy decreased the levels of IL-12 p40 accompanied by the anti-acetylcholine receptor antibody, but not anti-IL-12 p40 antibodies. These data strongly suggest the association of IL-12 p40 and its autoantibody with the immunopathology of MG with thymoma. |
| Databáze: | OpenAIRE |
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