Examination of the Gateway Hypothesis in a rat model
Autor: | Erin S. Barry, Neil E. Grunberg, Kevin S. Nishida, Kwang H. Choi, Kathryn E. Eklund |
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Rok vydání: | 2019 |
Předmět: |
Male
Drug Nicotine medicine.medical_treatment media_common.quotation_subject Clinical Biochemistry Rat model Physiology Self Administration Toxicology Biochemistry Rats Sprague-Dawley 03 medical and health sciences Behavioral Neuroscience 0302 clinical medicine Osmotic minipump Animals Medicine Saline Biological Psychiatry media_common Pharmacology Morphine business.industry Gateway (computer program) Late adolescence Rats 030227 psychiatry Models Animal Female business 030217 neurology & neurosurgery medicine.drug |
Zdroj: | Pharmacology Biochemistry and Behavior. 179:89-97 |
ISSN: | 0091-3057 |
Popis: | The Gateway Hypothesis is based on epidemiological data and states there is a progression of drug use from use of a softer drug (e.g., nicotine) to use of a harder drug (e.g., morphine). It has been suggested that this sequence is causal and is relevant to drug prevention policies and programs. The present experiment used an animal model to investigate whether the Gateway Hypothesis involves a causal progression. Subjects were 16 female and 16 male Sprague-Dawley rats with ages comparable to late adolescence/emerging adulthood in humans. Subjects received nicotine (6 mg/kg/day) or saline for 21 days SC via osmotic minipump and subsequently were allowed to self-administer IV morphine (0.5 mg/kg/injection, 3 h/day) for 10 days. Results did not confirm the Gateway Hypothesis. In fact, rats pre-exposed to nicotine self-administered significantly less morphine than did rats pre-exposed to saline. These findings may be relevant to future drug use prevention policies and programs. |
Databáze: | OpenAIRE |
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