Gain of chromosome arm 1q in patieznts in relapse and progression of multiple myeloma
| Autor: | Vlastimil Scudla, Jana Balcarkova, Marie Jarošová, Jaroslav Bačovský, Milena Holzerova, Karel Indrak, Helena Urbankova |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Oncology Cancer Research medicine.medical_specialty Biology Bioinformatics Immunophenotyping Recurrence Internal medicine Genetics medicine Humans Molecular Biology In Situ Hybridization Fluorescence Multiple myeloma Aged Segmental duplication Comparative Genomic Hybridization medicine.diagnostic_test Chromosome Middle Aged medicine.disease Chromosomes Human Pair 1 Chromosome Arm Disease Progression Female Multiple Myeloma Trisomy Fluorescence in situ hybridization Comparative genomic hybridization |
| Zdroj: | Cancer Genetics and Cytogenetics. 192:68-72 |
| ISSN: | 0165-4608 |
| DOI: | 10.1016/j.cancergencyto.2009.02.020 |
| Popis: | Abnormalities of chromosome 1 are among the most frequent chromosomal aberrations in patients with multiple myeloma (MM) and are considered a poor-risk genetic feature. To define the frequency and minimal region of 1q gain, we performed immunophenotyping and fluorescence in situ hybridization, comparative genomic hybridization (CGH), and array-CGH in 30 patients in relapse and progression of MM. Gain of 1q21 was found in 15 patients (50%), and in 14 of them whole-arm gain was found. One of these 14 patients had trisomy of chromosome 1 together with whole arm 1q gain, and two others had segmental duplication together with whole arm 1q gain. Segmental duplication of 1q21.1 approximately q23.1 alone was found in one patient. These results confirmed a high frequency of 1q aberrations and revealed that the vast majority of patients with 1q aberration in relapse and progression of MM display whole arm 1q gain. Finally, we observed that 1q gain is highly associated with number of additional changes. |
| Databáze: | OpenAIRE |
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