A monoclonal antibody and functional study of malignant T cells of a patient with suppressor-T-cell lymphoma
| Autor: | Syed Raziuddin, Nazir K. Hussain, Abdul Basit Abdul Latif |
|---|---|
| Rok vydání: | 1987 |
| Předmět: |
Lymphocyte Cooperation
Immunology chemical and pharmacologic phenomena Lymphocyte Activation T-Lymphocytes Regulatory Pathology and Forensic Medicine Interleukin 21 Concanavalin A Humans Immunology and Allergy Cytotoxic T cell Medicine IL-2 receptor Phytohemagglutinins Antigen-presenting cell Interleukin 3 business.industry Lymphoma Non-Hodgkin ZAP70 Antibodies Monoclonal hemic and immune systems Middle Aged Natural killer T cell Leukemia Lymphocytic Chronic B-Cell Phenotype Abdominal Neoplasms Cancer research Interleukin 12 Female Lymph Nodes business |
| Zdroj: | Clinical Immunology and Immunopathology. 45:230-234 |
| ISSN: | 0090-1229 |
| DOI: | 10.1016/0090-1229(87)90037-7 |
| Popis: | We describe the immunologic characteristics of malignant T cells of a T-cell lymphoma patient. The neoplastic cells in lymph node expressed OKT3+, OKT11−, E-rosetting−, OKT4−, OKT8+, OKIal+, OKDR+ suppressor-T-cell phenotype. Functionally, these malignant T cells did not respond to phytohemagglutinin, but produced a good response to concanavalin A. A defect in expression of interleukin 2 receptors was evident in phytohemagglutinin-activated T cells. In vitro immunoglobulin production experiments demonstrated that patient's malignant T cells possess helper function on normal B cells to produce IgM, and suppressor function to produce IgG. |
| Databáze: | OpenAIRE |
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