Cell-bound complement activation products as lupus biomarkers: diagnosis, monitoring and stratification
| Autor: | Susan Manzi, Joseph M. Ahearn, Chau-Ching Liu |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
030203 arthritis & rheumatology
Systemic lupus erythematosus business.industry Immunology Cell Complement System Proteins Precision medicine medicine.disease Complement system Complement (complexity) 03 medical and health sciences 0302 clinical medicine medicine.anatomical_structure medicine Immunology and Allergy Biomarker (medicine) Humans Lupus Erythematosus Systemic 030212 general & internal medicine business Complement Activation Expert Testimony Biomarkers Monitoring Physiologic |
| Zdroj: | Expert review of clinical immunology. 13(12) |
| ISSN: | 1744-8409 |
| Popis: | Cell-bound complement activation products (CB-CAPs) were first reported in 2004, since which time multiple laboratories have demonstrated their value as biomarkers for diagnosis, monitoring, and stratification of patients with systemic lupus erythematosus. Areas covered: This review summarizes the highlights of these 14 years of CB-CAPs discovery and validation, concluding with a view toward their future potential for precision medicine. Expert commentary: The practice of medicine is both art and science and each physician can be considered both artist and scientist with a variable blend of the two skill sets. There is arguably no disease that presents a greater challenge, nor a greater opportunity, for implementation of precision medicine, as does lupus. The physician who is presented with diagnosis and/or management of a patient suspected of having lupus will need to augment artistic skills with scientific guidance, and that science will be delivered in the form of biomarkers. Ultimately, we will likely have a 'lupus liquid biopsy' that will be 100% sensitive and 100% specific for a diagnosis of lupus. This will undoubtedly be a panel of biomarkers rather than an individual laboratory test. Such a liquid biopsy could transform lupus diagnosis to an entirely scientific process. |
| Databáze: | OpenAIRE |
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