Retroviral RNA Dimerization: From Structure to Functions
| Autor: | Jean-Christophe Paillart, Serena Bernacchi, Noé Dubois, Roland Marquet |
|---|---|
| Přispěvatelé: | Architecture et réactivité de l'ARN (ARN), Centre National de la Recherche Scientifique (CNRS)-Université Louis Pasteur - Strasbourg I |
| Jazyk: | angličtina |
| Rok vydání: | 2018 |
| Předmět: |
0301 basic medicine
Microbiology (medical) Dimer [SDV]Life Sciences [q-bio] viruses lcsh:QR1-502 Review Microbiology Genome lcsh:Microbiology 03 medical and health sciences chemistry.chemical_compound Retrovirus Viral life cycle Guide RNA structure ComputingMilieux_MISCELLANEOUS function dimerization biology RNA HIV Translation (biology) biology.organism_classification MuLV 3. Good health Cell biology retrovirus 030104 developmental biology chemistry Function (biology) |
| Zdroj: | Frontiers in Microbiology, Vol 9 (2018) Frontiers in Microbiology Frontiers in Microbiology, Frontiers Media, 2018, 9, ⟨10.3389/fmicb.2018.00527⟩ |
| ISSN: | 1664-302X |
| Popis: | The genome of the retroviruses is a dimer composed by two homologous copies of genomic RNA (gRNA) molecules of positive polarity. The dimerization process allows two gRNA molecules to be non-covalently linked together through intermolecular base-pairing. This step is critical for the viral life cycle and is highly conserved among retroviruses with the exception of spumaretroviruses. Furthermore, packaging of two gRNA copies into viral particles presents an important evolutionary advantage for immune system evasion and drug resistance. Recent studies reported RNA switches models regulating not only gRNA dimerization, but also translation and packaging, and a spatio-temporal characterization of viral gRNA dimerization within cells are now at hand. This review summarizes our current understanding on the structural features of the dimerization signals for a variety of retroviruses (HIVs, MLV, RSV, BLV, MMTV, MPMV…), the mechanisms of RNA dimer formation and functional implications in the retroviral cycle. |
| Databáze: | OpenAIRE |
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