Update on the management of fungal keratitis
| Autor: | Xiao-Yuan Sha, Jing-Xiang Zhong, Lian Liu, Qi Shi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
Keratitis
medicine.medical_specialty Corneal penetration Diagnostic methods Antifungal Agents Web of science business.industry medicine.disease Cornea 03 medical and health sciences Ophthalmology 0302 clinical medicine Drug Delivery Systems 030221 ophthalmology & optometry medicine Humans Fungal keratitis Intensive care medicine business Corneal Ulcer Eye Infections Fungal 030217 neurology & neurosurgery |
| Zdroj: | International ophthalmology. 41(9) |
| ISSN: | 1573-2630 |
| Popis: | The aim of this article is to introduce the recent advance on the studies of fungal keratitis published over past 5 years. We performed literature review of articles published on PubMed, Google Scholar, CNKI and Web of Science relevant to the diagnosis, pathogenesis and novel treatment of fungal keratitis. Excessive inflammation can lead to stromal damage and corneal opacification, hence the research on immune mechanism provides many potential therapeutic targets for fungal keratitis. Many researchers discussed the importance of earlier definitive diagnosis and were trying to find rapid and accurate diagnostic methods of pathogens. Develop new drug delivery systems and new routes of administration with better corneal penetration, prolonged ocular residence time, and better mucoadhesive properties is also one of the research hotspots. Additionally, many novel therapeutic agents and methods have been gradually applied in clinical ophthalmology. The diagnosis and treatment of fungal keratitis are still a challenge for ophthalmologist, and many researches provide new methods to conquer these problems. |
| Databáze: | OpenAIRE |
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