The origin and evolution of cell-intrinsic antibacterial defenses in eukaryotes
| Autor: | Daniel J. Richter, Tera C. Levin |
|---|---|
| Přispěvatelé: | National Institutes of Health (US), Generalitat de Catalunya |
| Jazyk: | angličtina |
| Rok vydání: | 2019 |
| Předmět: |
Reactive oxygen species metabolism
Protein domain Cell NLR Proteins Biology Bacterial Physiological Phenomena Article Evolution Molecular 03 medical and health sciences 0302 clinical medicine Phagocytosis Protein Domains Phylogenetics Genetics medicine Autophagy Phylogeny 030304 developmental biology 0303 health sciences Bacteria Host Microbial Interactions Extramural Toll-Like Receptors Pattern recognition receptor Eukaryota medicine.anatomical_structure Eukaryotic Cells Evolutionary biology Receptors Pattern Recognition Reactive Oxygen Species 030217 neurology & neurosurgery Developmental Biology |
| Zdroj: | Curr Opin Genet Dev Digital.CSIC. Repositorio Institucional del CSIC instname |
| Popis: | To survive in a world dominated by bacteria, eukaryotes have evolved numerous self-defense strategies. While some defenses are recent evolutionary innovations, others are ancient, with roots early in eukaryotic history. With a focus on antibacterial immunity, we highlight the evolution of pattern recognition receptors that detect bacteria, where diverse functional classes have been formed from the repeated use and reuse of a small set of protein domains. Next, we discuss core microbicidal strategies shared across eukaryotes, and how these systems may have been co-opted from ancient cellular mechanisms. We propose that studying antibacterial responses across diverse eukaryotes can reveal novel modes of defense, while highlighting the critical innovations that occurred early in the evolution of our own immune systems. DJR is supported by a postdoctoral fellowship from the Beatriu de Pinós programme of the Government of Catalonia’s Secretariat for Universities and Research of the Ministry of Economy and Knowledge. TCL is supported by a Pathway to Independence Award from the National Institute of Allergy and Infectious Disease and the National Institutes of Health (K99 AI139344). |
| Databáze: | OpenAIRE |
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