Nonalcoholic fatty liver disease with cirrhosis increases familial risk for advanced fibrosis
| Autor: | Alan W. Hemming, Lisa Richards, Yuko Kono, Rohit Loomba, Monica P. Gonzalez, Sandra Cepin, Chi-Hua Chen, Barbara Andrews, Jeffrey Cui, Cyrielle Caussy, Ricki Bettencourt, Shirin Bassirian, Michel H. Mendler, Claude B. Sirlin, Mahdi Al Ikhwan, Kristin L. Mekeel, David A. Brenner, Meera Soni, Jeffrey Haldorson, Joanie Salotti, Irine Vodkin, Nicholas J. Schork |
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| Rok vydání: | 2017 |
| Předmět: |
0301 basic medicine
Proband Adult Liver Cirrhosis Male medicine.medical_specialty Cirrhosis Gastroenterology 03 medical and health sciences 0302 clinical medicine Fibrosis Non-alcoholic Fatty Liver Disease Risk Factors Internal medicine Diabetes mellitus Nonalcoholic fatty liver disease medicine Humans Family Prospective Studies Prospective cohort study Aged business.industry General Medicine Odds ratio Middle Aged medicine.disease Magnetic Resonance Imaging 3. Good health 030104 developmental biology Cohort 030211 gastroenterology & hepatology Female business |
| Zdroj: | The Journal of clinical investigation. 127(7) |
| ISSN: | 1558-8238 |
| Popis: | Author(s): Caussy, Cyrielle; Soni, Meera; Cui, Jeffrey; Bettencourt, Ricki; Schork, Nicholas; Chen, Chi-Hua; Ikhwan, Mahdi Al; Bassirian, Shirin; Cepin, Sandra; Gonzalez, Monica P; Mendler, Michel; Kono, Yuko; Vodkin, Irine; Mekeel, Kristin; Haldorson, Jeffrey; Hemming, Alan; Andrews, Barbara; Salotti, Joanie; Richards, Lisa; Brenner, David A; Sirlin, Claude B; Loomba, Rohit; Familial NAFLD Cirrhosis Research Consortium | Abstract: BackgroundThe risk of advanced fibrosis in first-degree relatives of patients with nonalcoholic fatty liver disease and cirrhosis (NAFLD-cirrhosis) is unknown and needs to be systematically quantified. We aimed to prospectively assess the risk of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis.MethodsThis is a cross-sectional analysis of a prospective cohort of 26 probands with NAFLD-cirrhosis and 39 first-degree relatives. The control population included 69 community-dwelling twin, sib-sib, or parent-offspring pairs (n = 138), comprising 69 individuals randomly ascertained to be without evidence of NAFLD and 69 of their first-degree relatives. The primary outcome was presence of advanced fibrosis (stage 3 or 4 fibrosis). NAFLD was assessed clinically and quantified by MRI proton density fat fraction (MRI-PDFF). Advanced fibrosis was diagnosed by liver stiffness greater than 3.63 kPa using magnetic resonance elastography (MRE).ResultsThe prevalence of advanced fibrosis in first-degree relatives of probands with NAFLD-cirrhosis was significantly higher than that in the control population (17.9% vs. 1.4%, P = 0.0032). Compared with controls, the odds of advanced fibrosis among the first-degree relatives of probands with NAFLD-cirrhosis were odds ratio 14.9 (95% CI, 1.8-126.0, P = 0.0133). Even after multivariable adjustment by age, sex, Hispanic ethnicity, BMI, and diabetes status, the risk of advanced fibrosis remained both statistically and clinically significant (multivariable-adjusted odds ratio 12.5; 95% CI, 1.1-146.1, P = 0.0438).ConclusionUsing a well-phenotyped familial cohort, we demonstrated that first-degree relatives of probands with NAFLD-cirrhosis have a 12 times higher risk of advanced fibrosis. Advanced fibrosis screening may be considered in first-degree relatives of NAFLD-cirrhosis patients.Trial registrationUcsd irb140084.FundingNational Institute of Diabetes and Digestive and Kidney Diseases and National Institute of Environmental Health Sciences, NIH. |
| Databáze: | OpenAIRE |
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