Genomic Epidemiology and Heterogeneity of SRLV in Italy from 1998 to 2019
| Autor: | Claudia Torresi, Ilaria Pierini, Paola Gobbi, Moira Bazzucchi, Carmen Iscaro, Monica Giammarioli, Silvia Pirani, Francesco Feliziani |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Virulence Sheep Diseases SRLV Biology Microbiology Article genomic heterogeneity phylogenetic analyzes Virology Epidemiology medicine Animals Genetic variability Gene Genetics Genetic diversity Goat Diseases Sheep Phylogenetic tree Host (biology) Strain (biology) Goats Lentivirus Ruminants QR1-502 Infectious Diseases Italy Lentivirus Infections |
| Zdroj: | Viruses, Vol 13, Iss 2338, p 2338 (2021) Viruses Viruses; Volume 13; Issue 12; Pages: 2338 |
| ISSN: | 1999-4915 |
| Popis: | Small ruminant lentiviruses (SRLV) are viruses that retro-transcribe RNA to DNA and show high rates of genetic variability. SRLV affect animals with strains specific for each host species (sheep or goats), resulting in a series of clinical manifestations depending on the virulence of the strain, the host’s genetic background and farm production system. The aim of this work was to present an up-to-date overview of the genomic epidemiology and genetic diversity of SRLV in Italy over time (1998–2019). In this study, we investigated 219 SRLV samples collected from 17 different Italian regions in 178 geographically distinct herds by CEREL. Our genetic study was based on partial sequencing of the gag-pol gene (800 bp) and phylogenetic analysis. We identified new subtypes with high heterogeneity, new clusters and recombinant forms. The genetic diversity of Italian SRLV strains may have diagnostic and immunological implications that affect the performance of diagnostic tools. Therefore, it is extremely important to increase the control of genomic variants to improve the control measures. |
| Databáze: | OpenAIRE |
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