Restraint stress enhances alcohol intake in adolescent female rats but reduces alcohol intake in adolescent male and adult female rats

Autor: Ana Inés Ferreyra, Martina Sciangula, Aranza Wille-Bille, Michael E. Nizhnikov, Florencia Chiner, Ricardo Marcos Pautassi
Rok vydání: 2017
Předmět:
Male
Aging
STRESS
Narcotic Antagonists
Ciencias de la Salud
Alcohol abuse
ALCOHOL
Alcohol
Choice Behavior
Naltrexone
Behavioral Neuroscience
chemistry.chemical_compound
0302 clinical medicine
ADOLESCENTS
AGE DIFFERENCES
Sex Characteristics
Female
Psychology
medicine.drug
Sex characteristics
Restraint
Physical
medicine.medical_specialty
Elevated plus maze
CIENCIAS MÉDICAS Y DE LA SALUD
Alcohol Drinking
Motor Activity
03 medical and health sciences
Risk-Taking
Internal medicine
medicine
Animals
Rats
Wistar
Salud Ocupacional
Ethanol
Receptors
Opioid
kappa
Antagonist
Central Nervous System Depressants
ADULTS
medicine.disease
030227 psychiatry
Disease Models
Animal
Endocrinology
chemistry
Κ OPIOID RECEPTORS
Exploratory Behavior
Norbinaltorphimine
Stress
Psychological
030217 neurology & neurosurgery
Zdroj: Behavioural Brain Research. 332:269-279
ISSN: 0166-4328
DOI: 10.1016/j.bbr.2017.06.004
Popis: Adolescents may be more sensitive to stress-induced alcohol drinking than adults, which would explain the higher prevalence of alcohol abuse and dependence in late adolescence than in adulthood. The present study analyzed the impact of restraint stress on the initiation of alcohol intake across 2 weeks of intermittent, two-bottle choice intake in male and female adolescent rats and adult female rats. Restraint stress significantly increased alcohol intake and preference in female adolescent rats but decreased alcohol intake and preference in male adolescent and female adult rats. The effects of restraint stress on alcohol intake were mitigated in adolescent females following administration of the κ opioid receptor antagonist norbinaltorphimine. Adolescent but not adult female rats that were subjected to restraint stress spent more time on the open arms of the elevated plus maze. Female adolescents exposed to stress also exhibited greater risk-taking behaviors in a concentric square field test compared with non-stressed controls. These results indicate age- and sex-related differences in the sensitivity to alcohol-stress interactions that may facilitate the initiation of alcohol use in female adolescents. The facilitatory effect of stress on alcohol intake was related to greater exploratory and risk-taking behaviors in young females after stress exposure. Fil: Wille-bille, Aranza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Ferreyra, Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina Fil: Sciangula, Martina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Chiner, Florencia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina Fil: Nizhnikov, Michael. Southern Connecticut State University; Estados Unidos Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Databáze: OpenAIRE
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