Potential of Plant Proteins Digested In Silico by Gastrointestinal Enzymes as Nutritional Supplement for COVID-19 Patients
| Autor: | Keying Su, Xuewu Zhang, Zhen Luo |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Drug Protein supplementation Nutritional Supplementation media_common.quotation_subject In silico Pneumonia Viral Spike Protein degradation Peptidyl-Dipeptidase A medicine.disease_cause 03 medical and health sciences Betacoronavirus 0404 agricultural biotechnology medicine Humans Pandemics Coronavirus media_common Plant Proteins chemistry.chemical_classification Oligopeptide Original Paper 030109 nutrition & dietetics biology SARS-CoV-2 RuBisCO fungi COVID-19 04 agricultural and veterinary sciences 040401 food science Enzyme Biochemistry chemistry Chemistry (miscellaneous) Dietary Supplements Spike Glycoprotein Coronavirus biology.protein Coronavirus Infections Oligopeptides Food Science In silico evaluation |
| Zdroj: | Plant Foods for Human Nutrition (Dordrecht, Netherlands) Plant Foods for Human Nutrition |
| ISSN: | 1573-9104 0921-9668 |
| Popis: | Currently, no specific drug and vaccine are available for the new coronavirus SARS-CoV-2, and nutritional supplementation should be helpful. This study tried to provide reference for protein supplementation. Specifically, in silico method was employed to simulate protein degradation by gastrointestinal enzymes and to produce a large number of active peptides, then, the binding ability of these peptides to SARS-CoV-2 spike protein receptor-binding domain (RBD) was evaluated. The results showed that wheat-derived alpha/beta-gliadin, oat-derived avenin, and ribulose bisphosphate carboxylase small chain of different origin could be good protein source in generating potent binders to SARS-CoV-2 spike RBD. In addition, some high-affinity oligopeptides (such as PISCR, VQVVN, PQQQF, etc.) were identified as potential binders of SARS-CoV-2 spike RBD. In summary, a number of plant proteins could be helpful for COVID-19 patients when supplemented with these proteins, the identified oligopeptides could be used as lead compound to design potential entry inhibitors against SARS-CoV-2. |
| Databáze: | OpenAIRE |
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