Distribution of alpha3, alpha5 and alpha(v) integrin subunits in mature and immature human oocytes
| Autor: | V N Bolton, Josep Santaló, Gemma Capmany, M Mart |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Integrins
Embryology Indoles Integrin alpha3 Integrin Integrin alpha5 Biology Immunofluorescence Antigens CD Genetics medicine Humans Molecular Biology Metaphase Germinal vesicle medicine.diagnostic_test urogenital system Vesicle Obstetrics and Gynecology Cell Biology Integrin alphaV Oocyte Cell biology medicine.anatomical_structure Reproductive Medicine Cytoplasm embryonic structures Oocytes biology.protein Female Developmental Biology |
| Zdroj: | Molecular Human Reproduction. 4:951-956 |
| ISSN: | 1460-2407 |
| DOI: | 10.1093/molehr/4.10.951 |
| Popis: | The distribution of three integrin subunits, alpha3, alpha5 and alpha(v), in immature and mature human oocytes has been examined using immunofluorescence and confocal microscopy. The results demonstrate that both alpha5 and alpha(v) are present at the germinal vesicle stage, while alpha3 was only detected in oocytes after germinal vesicle breakdown, in metaphase I and II stage oocytes. The cortical concentration of integrin subunits alpha3 and alpha5 is consistent with their localization in the oolemma. In contrast, the homogeneous distribution of alpha(v) throughout the oocyte suggests the existence of cytoplasmic reservoirs of this protein in the oocyte. |
| Databáze: | OpenAIRE |
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