Patients with Covid-19 exhibit different immunological profiles according to their clinical presentation
| Autor: | A. Sindt, B. Seitz-Polski, A. Puchois, M. Ticchioni, Jacques Durant, S. Manni, Matteo Vassallo, E. Blanchouin, P. Fauque, L. Lotte, P. Pini |
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| Rok vydání: | 2020 |
| Předmět: |
Male
0301 basic medicine Microbiology (medical) medicine.medical_specialty Lymphocyte medicine.medical_treatment 030106 microbiology Population medicine.disease_cause Asymptomatic Article lcsh:Infectious and parasitic diseases 03 medical and health sciences 0302 clinical medicine Immune system Internal medicine Odds Ratio medicine Humans lcsh:RC109-216 Clinical severity 030212 general & internal medicine Immune response education B cell Aged Coronavirus Aged 80 and over Respiratory Distress Syndrome education.field_of_study SARS-CoV-2 business.industry General Medicine Odds ratio Middle Aged Hospitalization Infectious Diseases medicine.anatomical_structure Cytokine Female medicine.symptom Covid-19 business Biomarkers |
| Zdroj: | International Journal of Infectious Diseases International Journal of Infectious Diseases, Vol 101, Iss, Pp 174-179 (2020) |
| ISSN: | 1201-9712 |
| DOI: | 10.1016/j.ijid.2020.09.1438 |
| Popis: | Highlights • Patients with uncomplicated forms of Covid-19 have higher CD10 + B lymphocytes levels than subjects with complicated illness. • In complicated forms of Covid-19, plasma cytokines before clinical deterioration are predictive of death. • Differences in immunological response could explain the broad spectrum of clinical severity. Objectives A novel beta coronavirus has been identified as responsible for the 2019 coronavirus infection (Covid-19). Clinical presentations range from asymptomatic cases to acute respiratory distress syndrome with fatal outcome. Such a broad spectrum of disease expression calls for an investigation of immune response characteristics. Methods We identified subjects admitted for Covid-19 in whom a large panel of immunological markers were measured, including B- and T- and NK-lymphocyte phenotypes, T-lymphocyte subpopulation cells and plasma cytokines. Patients were divided according to symptom severity during hospitalisation, in those with uncomplicated and complicated infection. Differences between groups were analyzed. Results Seventeen patients were included (mean age: 83 years; 9 women; mean delay of symptoms onset: 4 days). Six had uncomplicated infection, while 11 developed complicated forms during the hospitalization. CD10 + B lymphocyte levels were inversely correlated with clinical severity (5.8% vs 2.0%, p = 0.04) and CD10+ levels above 3% were independently associated with uncomplicated forms [Odds Ratio 0.04 (CI 0.002-0.795, p = 0.034)]. TNF-alpha, IL-1, Il-6 and Il-8 measurements upon admission differed between patients who died and those who survived (p |
| Databáze: | OpenAIRE |
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