A variant in the CD209 promoter is associated with severity of dengue disease
| Autor: | Kanchana Tangnararatchakit, Wathanee Chaiyaratana, Pa-thai Yenchitsomanus, Yves Jacob, Sita Mint Kalayanarooj, Nattaya Tangthawornchaikul, Prapat Suriyaphol, Chairat Turbpaiboon, Prida Malasit, Cécile Julier, Sirijit Vasanawathana, Ampaiwan Chuansumrit, G. Mark Lathrop, Panisadee Avirutnan, Fumihiko Matsuda, Anavaj Sakuntabhai, Kulkanya Chokephaibulkit, Sutee Yoksan, Philippe Desprès, Isabelle Casademont, Tassanee Lowhnoo, Anna Kajaste-Rudnitski |
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| Přispěvatelé: | Génétique des Maladies Infectieuses et Autoimmunes, Institut Pasteur [Paris] (IP)-Institut National de la Santé et de la Recherche Médicale (INSERM), Department of Medicine, Faculty of Medicine, Mahidol University [Bangkok]-Ramathibodi Hospital, Department of Biochemistry, Faculty of Science, Department of Pediatrics, Faculty of Medicine, Centre National de Génotypage (CNG), Commissariat à l'énergie atomique et aux énergies alternatives (CEA), Research Center, Faculty of Medicine, Interactions Moléculaires Flavivirus-Hôtes, Institut Pasteur [Paris] (IP), Medical Molecular biology Unit, Faculty of Medicine, Mahidol University [Bangkok]-Siriraj Hospital, Medical Biotechnology Unit, National Center for Genetic Engineering and Biotechnology BIOTEC-National Science and Technology Development Agency [Bangkok] (NSTDA), Department of Pediatrics, Khon Kaen Hospital-Ministry of Public Health, Department of Pediatrics, Faculty of Medecine, Center for Vaccine Development, Mahidol University [Bangkok]-Institute of Science and Technology for Research and Development, Génétique, Papillomavirus et Cancer Humain, Institut Pasteur [Paris]-Institut National de la Santé et de la Recherche Médicale (INSERM), Institut Pasteur [Paris] |
| Jazyk: | angličtina |
| Rok vydání: | 2005 |
| Předmět: |
Population
Receptors Cell Surface MESH: Dengue Dengue virus medicine.disease_cause Severity of Illness Index Virus Article Dengue fever Dengue 03 medical and health sciences Flaviviridae 0302 clinical medicine MESH: Severity of Illness Index MESH: Polymorphism Genetic Genetics medicine Humans Lectins C-Type education Promoter Regions Genetic MESH: Receptors Cell Surface 0303 health sciences education.field_of_study MESH: Humans Polymorphism Genetic biology 030306 microbiology Odds ratio biology.organism_classification medicine.disease Virology 3. Good health MESH: Promoter Regions (Genetics) Flavivirus [SDV.MP.VIR]Life Sciences [q-bio]/Microbiology and Parasitology/Virology Immunology MESH: Cell Adhesion Molecules Viral disease Cell Adhesion Molecules MESH: Lectins C-Type 030215 immunology |
| Zdroj: | Nature Genetics Nature Genetics, 2005, 37 (5), pp.507-13. ⟨10.1038/ng1550⟩ Nature Genetics, Nature Publishing Group, 2005, 37 (5), pp.507-13. ⟨10.1038/ng1550⟩ |
| ISSN: | 1546-1718 1061-4036 |
| DOI: | 10.1038/ng1550⟩ |
| Popis: | Dengue fever and dengue hemorrhagic fever are mosquito-borne viral diseases. Dendritic cell–specific ICAM-3 grabbing nonintegrin (DC-SIGN1, encoded by CD209), an attachment receptor of dengue virus, is essential for productive infection of dendritic cells1,2. Here, we report strong association between a promoter variant of CD209, DCSIGN1-336, and risk of dengue fever compared with dengue hemorrhagic fever or population controls. The G allele of the variant DCSIGN1-336 was associated with strong protection against dengue fever in three independent cohorts from Thailand, with a carrier frequency of 4.7% in individuals with dengue fever compared with 22.4% in individuals with dengue hemorrhagic fever (odds ratio for risk of dengue hemorrhagic fever versus dengue fever: 5.84, P = 1.4 × 10−7) and 19.5% in controls (odds ratio for protection: 4.90, P = 2 × 10−6). This variant affects an Sp1-like binding site and transcriptional activity in vitro. These results indicate that CD209 has a crucial role in dengue pathogenesis, which discriminates between severe dengue fever and dengue hemorrhagic fever. This may have consequences for therapeutic and preventive strategies. Supplementary information The online version of this article (doi:10.1038/ng1550) contains supplementary material, which is available to authorized users. |
| Databáze: | OpenAIRE |
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