Use of granulocyte macrophage colony stimulating factor in children after orthotopic liver transplantation
| Autor: | Jean-Paul Buts, Pierre Maton, Etienne Sokal, Eunice Trindade, Jean-Bernard Otte, Jean de Ville de Goyet, Raymond Reding |
|---|---|
| Rok vydání: | 1998 |
| Předmět: |
Graft Rejection
medicine.medical_specialty Neutropenia Adolescent medicine.medical_treatment Liver transplantation Granulocyte Gastroenterology Tacrolimus Sepsis Leukocyte Count Postoperative Complications Internal medicine Medicine Humans Risk factor Child Hepatology business.industry Incidence Granulocyte-Macrophage Colony-Stimulating Factor Infant medicine.disease Surgery Liver Transplantation Transplantation Survival Rate Granulocyte macrophage colony-stimulating factor medicine.anatomical_structure Child Preschool Absolute neutrophil count business Immunosuppressive Agents medicine.drug |
| Zdroj: | Journal of hepatology. 28(6) |
| ISSN: | 0168-8278 |
| Popis: | BACKGROUND/AIMS: Bacterial infections complicate the course of up to 80% of pediatric liver transplant recipients, and in some cases, neutropenia, surgical complications and/or antibiotic resistance prevent successful control of sepsis. The aim of the present study was to evaluate the safety and efficacy of granulocyte macrophage colony stimulating factors (GM-CSF) in treating neutropenia following pediatric orthotopic liver transplantation. METHODS: Among a cohort of 430 pediatric orthotopic liver transplantation recipients, 13 children (12 months to 15 years, median 2 years, 10 males) received 15 courses of GM-CSF, 5 microg x kg(-1) x d(-1) subcutaneously, during their post-transplant course. In nine cases, the initial neutrophil count was below 1000/mm3. Ten patients were infected. Three received GM-CSF for severe sepsis without neutropenia. The mean duration of treatment was 16.3 days (range 4-49). RESULTS: In all but one neutropenic patient the neutrophil count increased above 1500/mm3 and the mean neutrophil count increased from 1392+/-1912/mm3 (range 130-7170, median 640) to 4508+/-2459/mm3 (range 350-9630, median 4390) (p |
| Databáze: | OpenAIRE |
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