Role of alfa2-adrenoceptors in the lateral parabrachial nucleus in the control of body fluid homeostasis

Autor: Patricia Maria De Paula, Patrícia Maria De Paula, GLAUCIA MARIA FABRICIO DE ANDRADE FRANZE, José Vanderlei Menani, Carina A. Fabrício de Andrade, Laurival Antonio De Luca Junior
Přispěvatelé: Universidade Estadual Paulista (Unesp)
Rok vydání: 2014
Předmět:
Zdroj: Brazilian Journal of Medical and Biological Research, Volume: 47, Issue: 1, Pages: 11-18, Published: 10 JAN 2014
SciELO
Currículo Lattes
Repositório Institucional da UNESP
Universidade Estadual Paulista (UNESP)
instacron:UNESP
Brazilian Journal of Medical and Biological Research v.47 n.1 2014
Brazilian Journal of Medical and Biological Research
Associação Brasileira de Divulgação Científica (ABDC)
instacron:ABDC
Brazilian Journal of Medical and Biological Research, Vol 47, Iss 1, Pp 11-18 (2014)
ISSN: 0100-879X
DOI: 10.1590/1414-431x20133308
Popis: Made available in DSpace on 2014-09-30T18:18:23Z (GMT). No. of bitstreams: 0 Previous issue date: 2014-01-10Bitstream added on 2014-10-01T14:03:57Z : No. of bitstreams: 1 S0100-879X2014000100011.pdf: 258243 bytes, checksum: 492697b800bc76cd5a8b1a12c4ab45f3 (MD5) Made available in DSpace on 2016-01-28T16:55:49Z (GMT). No. of bitstreams: 0 Previous issue date: 2014. Added 1 bitstream(s) on 2016-01-28T17:02:22Z : No. of bitstreams: 1 ISSN1414-431X-2014-47-01-11-18.pdf: 258243 bytes, checksum: 492697b800bc76cd5a8b1a12c4ab45f3 (MD5) Item merged in doublecheck by Luana Priscila Costa (luana@reitoria.unesp.br) on 2018-05-17T19:05:59Z Item was identical to item(s): 108564, 132734 at handle(s): http://hdl.handle.net/11449/109481, http://hdl.handle.net/11449/133605 Central α2-adrenoceptors and the pontine lateral parabrachial nucleus (LPBN) are involved in the control of sodium and water intake. Bilateral injections of moxonidine (α2-adrenergic/imidazoline receptor agonist) or noradrenaline into the LPBN strongly increases 0.3 M NaCl intake induced by a combined treatment of furosemide plus captopril. Injection of moxonidine into the LPBN also increases hypertonic NaCl and water intake and reduces oxytocin secretion, urinary sodium, and water excreted by cell-dehydrated rats, causing a positive sodium and water balance, which suggests that moxonidine injected into the LPBN deactivates mechanisms that restrain body fluid volume expansion. Pretreatment with specific α2-adrenoceptor antagonists injected into the LPBN abolishes the behavioral and renal effects of moxonidine or noradrenaline injected into the same area, suggesting that these effects depend on activation of LPBN α2-adrenoceptors. In fluid-depleted rats, the palatability of sodium is reduced by ingestion of hypertonic NaCl, limiting intake. However, in rats treated with moxonidine injected into the LPBN, the NaCl palatability remains high, even after ingestion of significant amounts of 0.3 M NaCl. The changes in behavioral and renal responses produced by activation of α2-adrenoceptors in the LPBN are probably a consequence of reduction of oxytocin secretion and blockade of inhibitory signals that affect sodium palatability. In this review, a model is proposed to show how activation of α2-adrenoceptors in the LPBN may affect palatability and, consequently, ingestion of sodium as well as renal sodium excretion. Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil Universidade Estadual Paulista Júlio de Mesquita Filho, Departamento de Fisiologia e Patologia, Araraquara, Rua Humaitá, 1680, Centro, CEP 14801903, SP, Brasil
Databáze: OpenAIRE
Externí odkaz: