Variations in Thyroid Function and Sleep in Healthy Young Men
| Autor: | J. E. Paddle-Ledinek, M. Malinek, J. P. Masterton, D. Winikoff, M. W. Johns, Y. C. Patel |
|---|---|
| Rok vydání: | 1975 |
| Předmět: |
Adult
Male medicine.medical_specialty Total plasma Physiological significance business.industry Diurnal temperature variation Thyroid Gland Healthy subjects Sleep REM Blood Proteins General Medicine Sleep in non-human animals Serum binding Blood proteins Circadian Rhythm Thyroxine Endocrinology Internal medicine Humans Triiodothyronine Medicine Thyroid function Sleep business |
| Zdroj: | Clinical Science. 49:629-632 |
| ISSN: | 0301-0538 |
| DOI: | 10.1042/cs0490629 |
| Popis: | Summary 1. The total serum thyroxine, tri-iodothyronine resin uptake, total plasma protein concentration and the free thyroxine index (FTI) were determined repeatedly, at 07.15, 13.00 and 22.30 hours over 4 days, in six healthy young men. 2. There was a significant diurnal variation in the total serum thyroxine concentration but this reflected changes in the binding capacity of serum proteins and in the total plasma protein concentration which could be explained by changes of posture. The FTI, and presumably therefore the free thyroxine concentration, varied very little with the time of day. 3. The FTI varied significantly from day to day in three of the six subjects, presumably as a result of changes in thyroxine secretion because the serum binding capacity did not vary. 4. The subjects' sleep at night was assessed by electro-encephalogram. On days when the FTI was highest for a particular subject his sleep was more fragmented by spontaneous awakenings, the amount of rapid-eye-movement sleep was reduced and that of delta-wave sleep was increased, implying that variations in thyroid function over a period of a few days in healthy subjects can be of physiological significance. The cause of thesevariations is uncertain. Correspondence: Dr M. W. Johns, MRC Environmental Physiology Unit (Annexe), 242 Pentonville Road, London N1 9LB. |
| Databáze: | OpenAIRE |
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