Genetic moderation of CO2-induced fear by 5-HTTLPR genotype
| Autor: | Inge Knuts, Jalet van Rozendaal, Lies Goossens, Gunter Kenis, Eric Griez, Jim van Os, Alessandro Colasanti, Gabriel Esquivel, Nele Jacobs, Koen Schruers, Marlies van Duinen, Hubert J.M. Smeets, Marieke Wichers |
|---|---|
| Přispěvatelé: | Psychiatrie & Neuropsychologie, RS: MHeNs - R3 - Neuroscience, Genetica & Celbiologie, RS: CARIM School for Cardiovascular Diseases, RS: GROW - School for Oncology and Reproduction |
| Rok vydání: | 2010 |
| Předmět: |
Male
Panic Disorder/genetics Fear Genotype Pharmacology (medical) panic disorder Serotonin Plasma Membrane Transport Proteins Cross-Over Studies Middle Aged anxiety Psychiatry and Mental health dosage/*adverse effects Anxiety Panic Disorder Female Drug medicine.symptom Psychology Serotonin Plasma Membrane Transport Proteins/*genetics Polymorphism Anxiety disorder Adult 5-HT transporter gene medicine.medical_specialty Visual analogue scale SLC6A4 Dose-Response Relationship Young Adult Genetic Double-Blind Method Internal medicine medicine Humans Psychiatry Alleles Pharmacology Psychiatric Status Rating Scales Polymorphism Genetic Carbon Dioxide/administration & Dose-Response Relationship Drug Panic disorder carbon dioxide Panic Carbon Dioxide medicine.disease Crossover study Endocrinology 5-HTTLPR |
| Zdroj: | Journal of Psychopharmacology, 25(1), 37-42. SAGE Publications Ltd Schruers, K, Esquivel, G, van Duinen, M, Wichers, M, Kenis, G, Colasanti, A, Knuts, I, Goossens, L, Jacobs, N, van Rozendaal, J, Smeets, H, van Os, J & Griez, E 2011, ' Genetic moderation of CO 2-induced fear by 5-HTTLPR genotype ', Journal of Psychopharmacology, vol. 25, no. 1, pp. 37-42 . https://doi.org/10.1177/0269881110372543 |
| ISSN: | 1461-7285 0269-8811 |
| DOI: | 10.1177/0269881110372543 |
| Popis: | Inhalation of an increased concentration of carbon dioxide (CO2) has been shown to induce a state of negative affect in healthy subjects that is closely related to the clinical phenomenon of panic. It has been suggested that the vulnerability to CO2 is moderated by differences in serotonin (5-HT) activity, caused by a functional polymorphism in the promoter region of the 5-HT transporter (5-HTTLPR) gene. Our aim was to examine the relationship between bi- and tri-allelic 5-HTTLPR genotype and the affective response to different dosages of inhaled CO2 in healthy volunteers. Ninety-six subjects performed a double inhalation of four mixtures containing, respectively, 0%, 9%, 17.5% and 35% CO2, following a double-blind, cross-over, randomized design. Affective responses were measured with a visual analogue scale for fear and the Panic Symptom List. 5-HTTLPR genotype was expressed as LL, SL and SS. Subjects with the SL and SS genotype reported less fear than LL subjects. A significant interaction effect was found between genotype and CO2 dosage: the SS genotype showed lower fear scores than the LL genotype, particularly in the 17.5% CO2 dose condition. The present study suggests that the dose-dependent fear reaction to CO2 is moderated by a polymorphism in the 5-HT transporter gene, particularly at intermediate CO2 dosages. It also underscores the usefulness of the introduction of an intermediate phenotype related to panic to reveal an underlying genetic vulnerability otherwise staying elusive. These results are in line with current theories on the role of 5-HT in both panic and respiration. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|