Intraoperative bleeding during vitrectomy for diabetic tractional retinal detachment with versus without preoperative intravitreal bevacizumab (IBeTra study)
| Autor: | Rodrigo Jorge, D da R Lucena, José Carlos Barbosa, Jefferson Augusto Santana Ribeiro, Ingrid U. Scott, R. A. Costa, L L de Figueiredo-Pontes |
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| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pars plana medicine.medical_specialty genetic structures Bevacizumab medicine.medical_treatment Eye disease Blood Loss Surgical Angiogenesis Inhibitors Vitrectomy Antibodies Monoclonal Humanized Injections Cellular and Molecular Neuroscience Ophthalmology Diabetes mellitus Humans Medicine Prospective Studies Aged Diabetic Retinopathy business.industry Retinal Detachment Antibodies Monoclonal Retinal detachment Diabetic retinopathy Middle Aged medicine.disease eye diseases Sensory Systems Surgery Vitreous Body Treatment Outcome medicine.anatomical_structure Erythrocyte Count Female business Preanesthetic Medication medicine.drug Retinopathy |
| Zdroj: | British Journal of Ophthalmology. 93:688-691 |
| ISSN: | 0007-1161 |
| DOI: | 10.1136/bjo.2008.151233 |
| Popis: | Aims: To compare the amount of intraoperative intraocular bleeding in patients with diabetes with macula-involving tractional retinal detachment (TRD) undergoing pars plana vitrectomy (PPV) with and without preoperative intravitreal bevacizumab (IVB) injection. Methods: An institutional study was carried out with consecutive patients with diabetic retinopathy and macula-involving TRD of recent (3 months) onset who were randomly assigned to PPV only (PPV group) or PPV combined with one IVB (1.5 mg/0.06 ml) injection 2 weeks prior to surgery (bevacizumab (BEV)/PPV group). All patients underwent 23-gauge PPV 3 weeks after baseline. The main outcome measure was erythrocyte count in the fluid retrieved from the vitrectomy cassette using a Neubauer counting chamber. Results: The study included 20 patients. The mean erythrocyte count was 14 865×10 3 (SD 19 332×10 3 ; median 4500×10 3 ) cells in the BEV/PPV group, and 176 240×10 3 (SD 108 375×10 3 ; median 166 600×10 3 ) cells in the PPV group. The mean erythrocyte count was significantly lower in the BEV/PPV group than in the PPV group (p Conclusion: Preoperative IVB injection was associated with reduced intraocular bleeding during 23-gauge PPV for diabetic macula-involving TRD. Further studies are needed to confirm our preliminary findings. Trial registration number: NCT00690768. |
| Databáze: | OpenAIRE |
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