Changes in glial fibrillary acidic protein immunoreactivity in the rat facial nucleus following various types of nerve lesions
| Autor: | J. R. Wolff, R. Laskawi |
|---|---|
| Rok vydání: | 1996 |
| Předmět: |
Pathology
medicine.medical_specialty Botulinum Toxins Time Factors medicine.medical_treatment Facial Muscles Injections Intramuscular Lesion 03 medical and health sciences 0302 clinical medicine Glial Fibrillary Acidic Protein medicine Animals Axon 030304 developmental biology Facial Nerve Injuries Denervation Trigeminal nerve 0303 health sciences Glial fibrillary acidic protein biology business.industry Rats Inbred Strains General Medicine Anatomy GFAP stain Immunohistochemistry Facial nerve Nerve Regeneration Rats Facial Nerve medicine.anatomical_structure nervous system Otorhinolaryngology Astrocytes biology.protein Female Trigeminal Nerve Injuries sense organs Axotomy medicine.symptom business 030217 neurology & neurosurgery |
| Zdroj: | European Archives of Oto-Rhino-Laryngology. 253 |
| ISSN: | 1434-4726 0937-4477 |
| DOI: | 10.1007/bf00179953 |
| Popis: | We report about changes on astrocytes in the facial nucleus of the rat following various types of peripheral nerve lesions. Astrocyte-specific glial fibrillary acidic protein (GFAP) was labeled by immunohistochemistry and served as a marker for these changes. Increased GFAP immunoreactivity was found in the facial nucleus on the lesioned side within 2-3 days after axotomy. This change lasted longer (up to 1 year) when axon regeneration was prevented or delayed by placing a metal clip on the proximal nerve stump. Lesion of the trigeminal nerve prior to axotomy reduced the degree of GFAP immunoreactivity. No side differences were observed after botulinum toxin application. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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