Exploiting Self-Association to Evaluate Enantiomeric Composition by Cyclic Ion Mobility–Mass Spectrometry

Autor:	Dale A. Cooper-Shepherd, Hernando J. Olivos, Zhaoxiang Wu, Martin E. Palmer
Rok vydání:	2022
Předmět:	Ion Mobility Spectrometry Tryptophan Stereoisomerism Mass Spectrometry Analytical Chemistry
Zdroj:	Analytical Chemistry. 94:8441-8448
ISSN:	1520-6882 0003-2700
DOI:	10.1021/acs.analchem.2c01212
Popis:	The characterization of enantiomers is an important analytical challenge in the chemical and life sciences. Thorough evaluation of the purity of chiral molecules is particularly required in the pharmaceutical industry where safety concerns are paramount. Assessment of the enantiomeric composition is still challenging and time-consuming, meaning that alternative approaches are required. In this study, we exploit the formation of dimers as diastereomeric pairs of enantiomers to affect separation by high resolution cyclic ion mobility-mass spectrometry. Using the example of (
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c18a687457e9a438b3feab4c7d0cd30 https://doi.org/10.1021/acs.analchem.2c01212 Zobrazit plný text záznamu