Biological evaluation of KRIBB3 analogs as a microtubule polymerization inhibitor
| Autor: | Jae Nyoung Kim, Sangku Lee, Hyeong Kyu Lee, Dong Cho Han, Byoung-Mog Kwon, Ki Deok Shin, Kab Seog Yoon |
|---|---|
| Rok vydání: | 2010 |
| Předmět: |
Anti mitotic
Stereochemistry Aryl Organic Chemistry Clinical Biochemistry Pharmaceutical Science Isoxazoles Anisoles Biochemistry Tubulin Modulators Microtubule polymerization Polymerization chemistry.chemical_compound Structure-Activity Relationship chemistry Microtubule Tubulin Drug Discovery Molecular Medicine Structure–activity relationship Humans Isoxazole Molecular Biology Biological evaluation |
| Zdroj: | Bioorganicmedicinal chemistry letters. 21(3) |
| ISSN: | 1464-3405 |
| Popis: | A series of KRIBB3 analogs were synthesized by modifying substituents at aryl moieties of KRIBB3 for examining structure-activity relationships, and their inhibitory activities on microtubule polymerization were evaluated. The presence of free phenolic hydrogens in aryl moieties of KRIBB3 analogs plays an important role in inhibition of microtubule polymerization. |
| Databáze: | OpenAIRE |
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