Effects of insulin on the proliferation and global gene expression profile of A7r5 cells

Autor:	Xiaotao Feng, Hui‑Ming Duan, Xiao‑Qi Huang
Rok vydání:	2021
Předmět:	0301 basic medicine MAPK/ERK pathway Cancer Research MAP Kinase Signaling System medicine.medical_treatment Myocytes Smooth Muscle p38 Mitogen-Activated Protein Kinases Phosphatidylinositol 3-Kinases 03 medical and health sciences 0302 clinical medicine Immunology and Microbiology (miscellaneous) Downregulation and upregulation Cell Movement Genetics medicine Animals Humans Insulin Phosphorylation Protein kinase A Molecular Biology Protein kinase B PI3K/AKT/mTOR pathway Cell Proliferation Mitogen-Activated Protein Kinase Kinases Chemistry TOR Serine-Threonine Kinases NF-kappa B General Medicine Atherosclerosis Rats Cell biology 030104 developmental biology Gene Expression Regulation 030220 oncology & carcinogenesis Signal transduction Transcriptome Proto-Oncogene Proteins c-akt Extracellular matrix organization
Zdroj:	Molecular Biology Reports. 48:1205-1215
ISSN:	1573-4978 0301-4851
DOI:	10.1007/s11033-021-06200-8
Popis:	Insulin contributes to atherosclerosis, but the potential mechanisms are kept unclear. In this study, insulin promoted proliferation of A7r5 cells. Microarray analysis indicated that insulin significantly changed 812 probe sets of genes, including 405 upregulated and 407 downregulated ones (fold change ≥ 1.5 or ≤ − 1.5; p
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c1650dff47bc87a4584b4b4746900f4 https://doi.org/10.1007/s11033-021-06200-8 Zobrazit plný text záznamu Full text from SpringerLink