High Dose Rate and External Beam Radiotherapy in Locally Advanced Prostate Cancer
| Autor: | Gustavo Arruda Viani, Antonio Cassio Assis Pellizzon, Paulo Eduardo Ribeiro dos Santos Novaes, JV Salvajoli, F.S. Guimarães, Alexandre A Jacinto |
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| Rok vydání: | 2009 |
| Předmět: |
Male
Oncology Cancer Research medicine.medical_specialty medicine.medical_treatment Brachytherapy Adenocarcinoma Androgen deprivation therapy Prostate cancer Internal medicine medicine Humans External beam radiotherapy Stage (cooking) Aged Neoplasm Staging Retrospective Studies Univariate analysis business.industry Prostatic Neoplasms Androgen Antagonists Dose-Response Relationship Radiation Middle Aged Prognosis medicine.disease High-Dose Rate Brachytherapy Prostate-specific antigen business Follow-Up Studies |
| Zdroj: | American Journal of Clinical Oncology. 32:187-190 |
| ISSN: | 0277-3732 |
| DOI: | 10.1097/coc.0b013e3181841f78 |
| Popis: | Purpose To report the outcomes and toxicity of high dose rate brachytherapy as a boost for localized prostate cancer. Materials and methods Between 1997 and 2000, the medical records of 131 patients with prostate adenocarcinoma who were treated with external beam radiation therapy and high dose rate brachytherapy, were retrospectively analyzed. Furthermore, 55% of the patients received neoadjuvant/concurrent or adjuvant androgen deprivation therapy. Patients were stratified into 2 groups. Group 1 included 65 patients with Gleason score 7, pretreatment prostate specific antigen (PSA) between 10 and 20 ng/mL, and clinical stage T2b. Group 2 included 66 patients with Gleason score between 8 and 10, PSA greater than 20 ng/mL, and clinical stage greater than T2b. Results At a median follow-up of 62.8 months, the 5-year biochemical control (BC) rate, as defined by the American Society for Therapeutic Radiology and Oncology Phoenix Consensus panel statement, was 81% and overall survival was 91%. BC in Groups 1 and 2 were 87% and 71%, respectively. On univariate analysis risk group, pretreatment PSA and age were significant predictors of BC. However, on multivariate analysis only pretreatment PSA was significant. Using the Radiation therapist oncology group criteria, there were 2 (1.5%) cases of grade 3 acute urinary toxicity. Regarding late side effects (n = 5), 4% of patients had grade 3 genitourinary toxicity and no grade 4 complication was observed. Conclusions External beam radiation therapy and high dose rate brachytherapy for prostate cancer resulted in excellent BC, and overall survival with minimal severe, acute, or late complications. |
| Databáze: | OpenAIRE |
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